Two dynamically distinct circuits drive inhibition in the sensory thalamus.

Nature
R. I. Martinez-GarciaScott J Cruikshank

Abstract

Most sensory information destined for the neocortex is relayed through the thalamus, where considerable transformation occurs1,2. One means of transformation involves interactions between excitatory thalamocortical neurons that carry data to the cortex and inhibitory neurons of the thalamic reticular nucleus (TRN) that regulate the flow of those data3-6. Although the importance of the TRN has long been recognised7-9, understanding of its cell types, their organization and their functional properties has lagged behind that of the thalamocortical systems they control. Here we address this by investigating the somatosensory and visual circuits of the TRN in mice. In the somatosensory TRN we observed two groups of genetically defined neurons that are topographically segregated and physiologically distinct, and that connect reciprocally with independent thalamocortical nuclei through dynamically divergent synapses. Calbindin-expressing cells-located in the central core-connect with the ventral posterior nucleus, the primary somatosensory thalamocortical relay. By contrast, somatostatin-expressing cells-which reside along the surrounding edges of the TRN-synapse with the posterior medial thalamic nucleus, a higher-order structure tha...Continue Reading

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Citations

Nov 28, 2020·Neuroscience and Biobehavioral Reviews·M WolffA Groh
Mar 17, 2021·The Journal of Comparative Neurology·Nidhi Vasant Desai, Carmen Varela
May 8, 2021·Nature Reviews. Neuroscience·Gordon M G Shepherd, Naoki Yamawaki
Apr 29, 2021·The Journal of Comparative Neurology·Courtney Michelle WhildenSolange Pezon Brown
May 26, 2021·The Journal of Comparative Neurology·Michael B Pritz
Aug 1, 2021·Nature Communications·Hanxiao LiuQiaojie Xiong
Sep 10, 2021·Brain Connectivity·Ilya Vyacheslavovich SysoevAnnika Lüttjohann

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