Two E3 ligases antagonistically regulate the UV-B response in Arabidopsis

Proceedings of the National Academy of Sciences of the United States of America
Hui RenXi Huang

Abstract

Photomorphogenesis is a pivotal developmental strategy used by plants to respond to environmental light levels. During emergence from the soil and the establishment of photomorphogenesis, seedlings encounter increasing levels of UV-B irradiation and develop adaptive responses accordingly. However, the molecular mechanisms that orchestrate UV-B signaling cascades remain elusive. Here, we provide biochemical and genetic evidence that the prolonged signaling circuits of UV-B-induced photomorphogenesis involve two sets of E3 ligases and a transcription factor in Arabidopsis thaliana The UV-B-inducible protein RUP1/RUP2 associates with the CUL4-DDB1 scaffold to form an E3 ligase, which represses photomorphogenesis by mediating the degradation of HY5, the hub transcription factor in the light signaling pathway. Conversely, COP1 directly targets RUP1/RUP2 for ubiquitination and degradation, leading to balanced RUP1/RUP2 accumulation, alleviation of the COP1-HY5 interaction, and stabilization of HY5 protein. Therefore, our study reveals that these two E3-substrate modules, CUL4-DDB1-RUP1/RUP2-HY5 and COP1-RUP1/RUP2, constitute the repression and derepression machinery by which plants respond to prolonged UV-B irradiation in photomorpho...Continue Reading

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Citations

Apr 8, 2020·The New Phytologist·Xinyang LiaoGareth I Jenkins
Apr 3, 2020·Journal of Integrative Plant Biology·Arpita YadavSourav Datta
May 22, 2020·The Plant Journal : for Cell and Molecular Biology·Premachandran YadukrishnanSourav Datta
Apr 9, 2020·International Journal of Molecular Sciences·Guizhen LyuShaoshan Li
Sep 29, 2020·The New Phytologist·Premachandran Yadukrishnan, Sourav Datta
Jan 26, 2021·Plant Science : an International Journal of Experimental Plant Biology·Chitra BhatiaPrabodh Kumar Trivedi
Feb 6, 2021·Proceedings of the National Academy of Sciences of the United States of America·Roman PodolecRoman Ulm
May 15, 2020·Trends in Plant Science·Yang Xu, Ziqiang Zhu
Feb 28, 2021·Annual Review of Plant Biology·Roman PodolecRoman Ulm
Aug 19, 2021·Proceedings of the National Academy of Sciences of the United States of America·Han Yong LeeGyeong Mee Yoon
Sep 1, 2021·Plant Signaling & Behavior·Tingting MiaoYan Wang
Aug 29, 2021·Physiologia Plantarum·María Lorena Falcone FerreyraPaula Casati

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