Two evolutionary models for the interactions of dietary organic cyanogens, hemoglobins, and falciparum malaria

American Journal of Human Biology : the Official Journal of the Human Biology Council
Fatimah Linda Collier Jackson

Abstract

Significant regional and ethnic variations in hemoglobin S frequencies among 485 adult nonpregnant Liberian women uniformly exposed to holoendemic falciparum malaria suggest that an additional major factor may influence the distribution of this hemoglobinopathy and the severity of the infectious disease with which it is causally associated. The differential consumption of organic cyanogen-rich cassava (Manihot esculenta) foodstuffs and subsequent dosage-dependent in vivo exposure to sublethal CN(-) , SCN(-) , and CNO(-) may directly interact with hemoglobin S by inhibiting sickling diathesis, and, at higher intakes, this dietary factor may adversely affect Plasmodium survival and antigenicity. In this study, low dietary organic cyanogen intakes (0.3 mg CN(-) /kg body wt/day) in NW and W geographical areas are associated with higher regional hemoglobin S gene frequencies (11%; phenotypic incidence 20%), lower mean (± SD) positive Plasmodium antibody titers (861.6 ± 102.4), and a higher mean (± SEM) prevalence of clinical falciparum malaria [3.04 times (± 0.09) within the previous 12 months]. In contrast, high dietary organic cyanogen intakes (1.5 mg CN(-) /kg body wt/day in SE and C geographical areas) are associated with lower ...Continue Reading

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Citations

Jun 6, 2017·International Journal of Tryptophan Research : IJTR·Adrian C Williams, Lisa J Hill
Nov 15, 2006·American Journal of Physical Anthropology·Eugene E Harris, Diogo Meyer
Dec 1, 1992·FEMS Microbiology Letters·M Q WeiW B Grubb
Jul 19, 2020·American Journal of Human Biology : the Official Journal of the Human Biology Council·Morgan K Hoke, Lawrence M Schell
Mar 26, 2003·Annual Review of Nutrition·Leslie Sue Lieberman
Jun 23, 1999·American Journal of Physical Anthropology·G Destro-BisolV Pascali
Oct 25, 2008·American Journal of Human Biology : the Official Journal of the Human Biology Council·Katherine WanderThomas W McDade
Jul 3, 2008·Annual Review of Genomics and Human Genetics·Michael C Campbell, Sarah A Tishkoff
Mar 21, 2008·Proceedings. Biological Sciences·Roger J SullivanPeter Hammerstein
Apr 2, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Henrik EnghoffMaurizio G Paoletti
Feb 26, 2011·International Journal of Evolutionary Biology·Hong Shi, Bing Su
Jul 30, 2005·Current Biology : CB·Nicole SoranzoDavid B Goldstein

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