Abstract
Significant regional and ethnic variations in hemoglobin S frequencies among 485 adult nonpregnant Liberian women uniformly exposed to holoendemic falciparum malaria suggest that an additional major factor may influence the distribution of this hemoglobinopathy and the severity of the infectious disease with which it is causally associated. The differential consumption of organic cyanogen-rich cassava (Manihot esculenta) foodstuffs and subsequent dosage-dependent in vivo exposure to sublethal CN(-) , SCN(-) , and CNO(-) may directly interact with hemoglobin S by inhibiting sickling diathesis, and, at higher intakes, this dietary factor may adversely affect Plasmodium survival and antigenicity. In this study, low dietary organic cyanogen intakes (0.3 mg CN(-) /kg body wt/day) in NW and W geographical areas are associated with higher regional hemoglobin S gene frequencies (11%; phenotypic incidence 20%), lower mean (± SD) positive Plasmodium antibody titers (861.6 ± 102.4), and a higher mean (± SEM) prevalence of clinical falciparum malaria [3.04 times (± 0.09) within the previous 12 months]. In contrast, high dietary organic cyanogen intakes (1.5 mg CN(-) /kg body wt/day in SE and C geographical areas) are associated with lower ...Continue Reading
References
May 1, 1975·The American Journal of Tropical Medicine and Hygiene·H M MathewsI G Kagan
Jul 1, 1979·Acta paediatrica Scandinavica·A MebergJ T Stenwig
Aug 1, 1979·Annals of Tropical Medicine and Parasitology·P HedmanE Bengtsson
Jun 7, 1977·Journal of Theoretical Biology·K J Vener
Aug 1, 1977·Journal of the Science of Food and Agriculture·O O TeweG Gomez
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·A C WilsonM C King
Jun 1, 1975·Journal of Medical Genetics·M C WillcoxJ B Clegg
Feb 1, 1988·Biochemical Medicine and Metabolic Biology·L C JacksonY L Kim
Jan 1, 1985·Social Science & Medicine·L C Jackson
Mar 25, 1972·Lancet·A MayG H Beaven
Oct 19, 1972·The New England Journal of Medicine·A Cerami
Nov 1, 1973·The American Journal of Clinical Nutrition·R G Houston
Sep 1, 1973·Cell and Tissue Kinetics·B Schultze, W Maurer
Mar 1, 1972·The Journal of Clinical Investigation·F G De FuriaJ M Manning
Jul 1, 1971·Annals of Human Genetics·R A Kempton
Jan 1, 1981·World Review of Nutrition and Dietetics·B O Osuntokun
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J S WylesA C Wilson
Mar 1, 1981·International Journal of Epidemiology·I Guggenmoos-HolzmannL Luzzatto
Nov 19, 1982·Science·J H Cock
Feb 6, 1954·British Medical Journal·A C ALLISON
Jan 18, 1964·Lancet·M KELLY
Aug 1, 1965·The American Journal of Clinical Nutrition·R D MONTGOMERY
Citations
Jun 6, 2017·International Journal of Tryptophan Research : IJTR·Adrian C Williams, Lisa J Hill
Apr 23, 2008·Annals of Human Biology·F L C Jackson
Nov 15, 2006·American Journal of Physical Anthropology·Eugene E Harris, Diogo Meyer
Dec 1, 1992·FEMS Microbiology Letters·M Q WeiW B Grubb
Jul 19, 2020·American Journal of Human Biology : the Official Journal of the Human Biology Council·Morgan K Hoke, Lawrence M Schell
Mar 26, 2003·Annual Review of Nutrition·Leslie Sue Lieberman
Jun 23, 1999·American Journal of Physical Anthropology·G Destro-BisolV Pascali
Oct 25, 2008·American Journal of Human Biology : the Official Journal of the Human Biology Council·Katherine WanderThomas W McDade
Jul 3, 2008·Annual Review of Genomics and Human Genetics·Michael C Campbell, Sarah A Tishkoff
Mar 21, 2008·Proceedings. Biological Sciences·Roger J SullivanPeter Hammerstein
Apr 2, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Henrik EnghoffMaurizio G Paoletti
Feb 26, 2011·International Journal of Evolutionary Biology·Hong Shi, Bing Su
Jul 30, 2005·Current Biology : CB·Nicole SoranzoDavid B Goldstein