Two faces of the coin: Minireview for dissecting the role of reactive oxygen species in stem cell potency and lineage commitment

Journal of Advanced Research
Ahmed NugudAhmed T El-Serafi

Abstract

Reactive oxygen species (ROS) are produced as by-products of several intracellular metabolic pathways and are reduced to more stable molecules by several protective pathways. The presence of high levels of ROS can be associated with disturbance of cell function and could lead to apoptosis. The presence of ROS within the physiological range has many effects on several signalling pathways. In stem cells, this role can range between keeping the potency of the naive stem cells to differentiation towards a certain lineage. In addition, the level of certain ROS would change according to the differentiation stage. For example, the presence of ROS can be associated with increasing the proliferation of mesenchymal stem cells, decreasing the potency of embryonic stem cells and adding to the genomic stability of induced pluripotent stem cells. ROS can enhance the differentiation of stem cells into cardiomyocytes, adipocytes, endothelial cells, keratinocytes and neurons. In the meantime, ROS inhibits osteogenesis and enhances the differentiation of cartilage to the hypertrophic stage, which is associated with chondrocyte death. Thus, ROS may form a link between naïve stem cells in the body and the environment. In addition, monitoring of RO...Continue Reading

Citations

Jan 11, 2020·Proceedings of the National Academy of Sciences of the United States of America·Antonin LevyGiulia Nigro
Sep 9, 2019·Lasers in Medical Science·Arezoo Rezaie Nezhad ZamaniReza Rahbarghazi
Sep 11, 2020·Oxidative Medicine and Cellular Longevity·Jialiang LiangPing Zhu
Mar 27, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Thunwa BinlatehPilaiwanwadee Hutamekalin
May 15, 2019·International Journal of Molecular Sciences·Ekaterina S KovelNadezhda S Kudryasheva
Jul 3, 2021·Antioxidants·Tullia MaraldiSilvana Hrelia
Jun 26, 2021·Tissue & Cell·Lydia SegallaAndrea Sbarbati
Jul 31, 2021·Journal of Experimental & Clinical Cancer Research : CR·Daniel Otero-Albiol, Amancio Carnero
Jun 6, 2021·Stem Cells·Dario BrunettiAlessandro Prigione

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Methods Mentioned

BETA
transfection
dissection

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