Two families of rep-like genes that probably originated by interspecies recombination are represented in viral, plasmid, bacterial, and parasitic protozoan genomes

Molecular Biology and Evolution
M J GibbsBoris A Efimov

Abstract

Two families of genes related to, and including, rolling circle replication initiator protein (Rep) genes were defined by sequence similarity and by evidence of intergene family recombination. The Rep genes of circoviruses were the best characterized members of the "RecRep1 family." Other members of the RecRep1 family were Rep-like genes found in the genomes of the Canarypox virus, Entamoeba histolytica, and Giardia duodenalis and in a plasmid, p4M, from the Gram-positive bacterium, Bifidobacterium pseudocatenulatum. The "RecRep2 family" comprised some previously identified Rep-like genes from plasmids of phytoplasmas and similar Rep-like genes from the genomes of Lactobacillus acidophilus, Lactococcus lactis, and Phytoplasma asteris. Both RecRep1 and RecRep2 proteins have a nucleotide-binding domain significantly similar to the helicases (2C proteins) of picorna-like viruses. On the N-terminal side of the nucleotide binding domain, RecRep1 proteins have a domain significantly similar to one found in nanovirus Reps, whereas RecRep2 proteins have a domain significantly similar to one in the Reps of pLS1 plasmids. We speculate that RecRep genes have been transferred from viruses or plasmids to parasitic protozoan and bacterial ge...Continue Reading

References

Jan 1, 1997·The Journal of General Virology·B M MeehanD Todd
Jul 1, 1997·The Journal of General Virology·G J HafnerJ L Dale
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·S E BrennerT J Hubbard
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·M J Gibbs, G F Weiller
Aug 31, 2000·Journal of Molecular Biology·C NotredameJ Heringa
Jun 25, 2004·Nucleic Acids Research·Aron Marchler-Bauer, Stephen H Bryant

❮ Previous
Next ❯

Citations

Jul 12, 2013·The ISME Journal·Jessica M Labonté, Curtis A Suttle
Aug 19, 2008·Applied and Environmental Microbiology·Kyoung-Ho KimJin-Woo Bae
Apr 30, 2013·Journal of Bacteriology·Cris Fernández-LópezD Roeland Boer
Sep 9, 2011·Journal of Virology·Tongling ShanEric Delwart
Sep 2, 2010·Microbiology and Molecular Biology Reviews : MMBR·Ju-Hoon Lee, Daniel J O'Sullivan
Jun 30, 2011·BMC Evolutionary Biology·Federica SaccardoGiuseppe Firrao
May 23, 2009·BMC Evolutionary Biology·Mart KrupovicDennis H Bamford
Mar 8, 2013·PloS One·Mitsuhiro YoshidaKen Takai
Sep 13, 2011·PLoS Pathogens·Tung G PhanEric L Delwart
Oct 14, 2011·Viruses·Darren P MartinArvind Varsani
Oct 23, 2014·BMC Genomics·Saskia Metzler, Olga V Kalinina
Jun 13, 2015·International Journal of Molecular Sciences·Yanhua CuiAijun Dong
Feb 16, 2011·International Journal of Food Microbiology·Michelle CroninDouwe van Sinderen
Aug 27, 2010·Trends in Parasitology·Jacqui A UpcroftPeter Upcroft
May 1, 2009·Microbial Biotechnology·Mary O'Connell MotherwayDouwe Van Sinderen
Sep 18, 2009·The Journal of General Virology·Olga BlinkovaEric L Delwart
Jul 3, 2009·The Journal of General Virology·Karyna RosarioMya Breitbart
Mar 17, 2015·Virology·Eugene V KooninMart Krupovic
Feb 24, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Anisha DayaramArvind Varsani
May 23, 2014·Microbiology and Molecular Biology Reviews : MMBR·Eugene V Koonin, Valerian V Dolja
Oct 11, 2019·Journal of Molecular Evolution·Győző L KajánTibor Papp
May 31, 2019·Virusdisease·V G Malathi, P Renuka Devi
Sep 17, 2020·Nature Communications·Cormac M KinsellaLia van der Hoek
Sep 10, 2021·Journal of Evolutionary Biology·Lele ZhaoSiobain Duffy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amoebiasis

Amoebiasis, infection by the protozoan parasite Entamoeba histolytica, remains a global health problem, despite the availability of effective treatment. Here is the latest research.