PMID: 9548231Jul 1, 1997Paper

Two forms of hippocampal long-term depression, the counterpart of long-term potentiation

Reviews in the Neurosciences
T Manabe

Abstract

In the hippocampus there are two distinct forms of long-term depression (LTD) of excitatory synaptic transmission. In the CA1 region, prolonged low-frequency stimulation induces LTD by activating postsynaptic NMDA receptors, which causes a moderate rise in Ca2+ concentrations. In mossy fiber synapses of the CA3 region, similar low-frequency stimulation also gives rise to LTD. However, this form of LTD (mossy fiber LTD) does not require activation of NMDA receptors, but is mediated by activation of presynaptic metabotropic glutamate receptors. Induction of mossy fiber LTD is not dependent on postsynaptic depolarization or activation of postsynaptic ionotropic glutamate receptors, thus it is likely to be mediated by purely presynaptic mechanisms. This conclusion is confirmed by the analysis of mutant mice lacking presynaptic mGluR2, in which mossy fiber LTD is almost absent. Since long-term potentiation at mossy fiber synapses is also induced presynaptically, the synaptic efficacy may be regulated through common mechanisms bidirectionally, which may contribute to neural information processing in the hippocampus.

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Citations

Dec 3, 1999·The European Journal of Neuroscience·M TakitaS S Suzuki
Feb 7, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Lara M SchraderItzhak Fried
Jun 30, 2012·Neuropharmacology·Sreedeep Mukherjee, Denise Manahan-Vaughan
Aug 25, 2007·Behavioral and Cognitive Neuroscience Reviews·Jonathan R Wolpaw
May 4, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gemma McGregorJenni Harvey
Jan 12, 2001·Physiological Reviews·J T WilliamsO Manzoni

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