Two forms of spiral-wave reentry in an ionic model of ischemic ventricular myocardium

Chaos
Aoxiang Xu, Michael R. Guevara

Abstract

It is well known that there is considerable spatial inhomogeneity in the electrical properties of heart muscle, and that the many interventions that increase this initial degree of inhomogeneity all make it easier to induce certain cardiac arrhythmias. We consider here the specific example of myocardial ischemia, which greatly increases the electrical heterogeneity of ventricular tissue, and often triggers life-threatening cardiac arrhythmias such as ventricular tachycardia and ventricular fibrillation. There is growing evidence that spiral-wave activity underlies these reentrant arrhythmias. We thus investigate whether spiral waves might be induced in a realistic model of inhomogeneous ventricular myocardium. We first modify the Luo and Rudy [Circ. Res. 68, 1501-1526 (1991)] ionic model of cardiac ventricular muscle so as to obtain maintained spiral-wave activity in a two-dimensional homogeneous sheet of ventricular muscle. Regional ischemia is simulated by raising the external potassium concentration ([K(+)](o)) from its nominal value of 5.4 mM in a subsection of the sheet, thus creating a localized inhomogeneity. Spiral-wave activity is induced using a pacing protocol in which the pacing frequency is gradually increased. Whe...Continue Reading

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Citations

Dec 23, 2003·Medical & Biological Engineering & Computing·K T Ng, R Yan
Jun 5, 2003·Chaos·Humberto ArceMichael R. Guevara
Jun 5, 2003·Chaos·David J. Christini, Leon Glass
Mar 3, 2004·The Journal of Clinical Investigation·Fagen XieAlan Garfinkel
Apr 8, 2006·Chaos·Hermann Riecke, Santiago Madruga
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Aug 21, 2007·Journal of Theoretical Biology·Alejandro LópezMichael R Guevara
Dec 18, 2003·Journal of Cardiovascular Electrophysiology·James P Keener
Aug 15, 2006·Mathematical Biosciences·Hong ZhangYi-Zhuo Huang
Nov 25, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Zhilin QuJames N Weiss
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Apr 24, 2002·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·P Comtois, A Vinet
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Aug 12, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Rupamanjari MajumderA V Panfilov
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May 1, 2017·Chaos·Lucas CampanariAlvin Shrier
Mar 17, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Sylvain BouchardAlain Vinet
Nov 7, 2014·Physical Review Letters·Thomas QuailLeon Glass
Mar 23, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Fatemeh CheginiMartin Weiser

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