Two-frequency analysis of respiratory mechanics in artificially ventilated rabbits

Respiration Physiology
R PeslinC Duvivier


The frequency dependence of respiratory mechanical properties was studied in 10 paralyzed, artificially ventilated rabbits, by superimposing a single sinusoidal signal with a frequency of 10, 20 or 30 Hz upon the ventilator waveform. The tracheal pressure and flow signals were analyzed both with the usual first order model, which provided total respiratory elastance (Ers) and resistance (Rrs), and by Fourier analysis, which provided respiratory impedance (Zrs) at the breathing frequency (0.85 Hz) and at the superimposed oscillation frequency. The real part of Zrs (Re(Zrs)) decreased by 30% from 0.85 to 10 Hz (P < 0.001), but did not vary significantly from 10 to 30 Hz. This finding is satisfactorily explained by tissue viscoelasticity. Following a histamine aerosol, the frequency dependence of Re(Zrs) changed very little in three out of four rabbits, but increased substantially in the fourth. In that instance, assuming that lung hysteresivity was not markedly modified by histamine, the results suggest inhomogeneous airway obstruction and/or airway wall shunting.


Nov 1, 1975·The Journal of Clinical Investigation·E D MichaelsonW R Peters
Dec 1, 1992·Respiration Physiology·P DewachterM C Laxenaire
Nov 1, 1991·Respiration Physiology·R PeslinC Choné
Jul 1, 1989·The American Review of Respiratory Disease·K J SullivanH K Chang

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Nov 27, 2007·Respiratory Physiology & Neurobiology·François MarchalNoëlle Bertin
Jan 31, 2002·Anesthesiology·Walid HabreFerenc Peták

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