Two-generation reproduction toxicity study in rats with methoxychlor

Congenital Anomalies
Hiroaki AoyamaShoji Teramoto

Abstract

A two-generation reproduction toxicity study was conducted in rats with a reference estrogenic pesticide, methoxychlor, to validate the sensitivity and competency of current guidelines recommended by the United States Environmental Protection Agency; Japanese Ministry of Agriculture, Forestry and Fisheries; and Organisation for Economic Co-operation and Development for predicting reproductive toxicity of the test compound based on estrogenic endocrine disrupting effects. Both sexes of SD rats were exposed to methoxychlor in the diet at concentrations of 0, 10, 500 and 1500 ppm for two successive generations. The present study has successfully detected estrogenic activities and reproductive toxicities of methoxychlor, as well as its systemic toxicity. Body weights, body weight gains and food consumption of both sexes of animals were suppressed significantly in the 500 and 1500 ppm groups. Typical reproductive toxicities observed in females of these groups included, but were not limited to, prolonged estrous cycle, reduced fertility, decreased numbers of implantation sites and newborns, decreased ovary weights and/or increased incidences of cystic ovary. Uterine weights of weanlings increased significantly in these groups, sugges...Continue Reading

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Citations

Oct 4, 2015·Environmental Toxicology and Pharmacology·Karanpreet KaurJatinder Paul Singh Gill
Jan 7, 2015·Congenital Anomalies·Keitaro HirawatariHideo Gotoh
Apr 26, 2015·Regulatory Toxicology and Pharmacology : RTP·Karen BlackburnKara Woeller
Mar 4, 2014·Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis·Akira SatoHiroaki Aoyama
Jan 10, 2020·Environmental and Molecular Mutagenesis·Rajnesh Kumar SharmaAman Kumar Sharma
Mar 31, 2017·The Journal of Endocrinology·Saniya RattanJodi A Flaws
Nov 28, 2021·Nutrients·Anastasia Konstantina SakaliMaria Papagianni

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