Two-generation reproductive toxicity evaluation of dietary 17beta-estradiol (E2; CAS No. 50-28-2) in CD-1 (Swiss) mice

Toxicological Sciences : an Official Journal of the Society of Toxicology
R W TylSteven G Hentges

Abstract

No information exists on reproductive/developmental effects in mice exposed to dietary 17beta-estradiol (E2) over multiple generations. Therefore, under OECD Test Guideline 416 with enhancements, CD-1 mice (F0 generation, 25 mice/sex/group) were exposed to dietary E2 at 0, 0.001, 0.005, 0.05, 0.15, or 0.5 ppm ( approximately 0, 0.2, 1, 10, 30, or 100 mug E2/kg body weight/day) for 8 weeks prebreed, 2 weeks mating, approximately 3 weeks gestation, and 3 weeks lactation. At weaning, selected F1 offspring (F1 parents; 25/sex/group) and extra retained F1 males (one per litter) were exposed to the same dietary concentrations and durations as the F0 generation; study termination occurred at F2 weaning; F1/F2 weanlings (up to three per sex per litter) were necropsied with organs weighed. At 0.5 ppm, effects were increased F1/F2 perinatal loss, prolonged F0/F1 gestational length, reduced numbers of F2 (but not F1) litters/group, reduced F1/F2 litter sizes, accelerated vaginal patency (VP) and delayed preputial separation (PPS), increased uterus + cervix + vagina weights (UCVW) in F0/F1 adults and F1/F2 weanlings, and decreased testes and epididymides weights (TEW) in F1/F2 weanlings. At 0.15 ppm, effects were increased UCVW in F0/F1 ad...Continue Reading

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Citations

Jan 7, 2014·Seminars in Fetal & Neonatal Medicine·Rochelle W Tyl
May 1, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rochelle W TylJohn M Waechter
Feb 19, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Donald G StumpSteven G Hentges
Apr 25, 2007·Neurobiology of Aging·Mari S GolubPatricia B Hoyer
Dec 8, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Mari S GolubJames M Donald
Jun 1, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Herman AutrupNico P Vermeulen
Aug 5, 2010·Journal of Applied Toxicology : JAT·Yoko Hirabayashi, Tohru Inoue
Oct 3, 2009·The Journal of Toxicological Sciences·Rochelle W Tyl
Jun 1, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Leon Earl GrayKevin M Crofton
Mar 29, 2011·Critical Reviews in Toxicology·J G HengstlerU Gundert-Remy

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