PMID: 9179723May 1, 1997Paper

Two-generation reproductive toxicity study of methyl tertiary-butyl ether (MTBE) in rats

Journal of Applied Toxicology : JAT
C BevanL S Andrews

Abstract

A two-generation reproductive toxicity study of methyl tertiary-butyl ether (MTBE) was conducted in Sprague-Dawley rats. Twenty-five rats of each sex (F0) were exposed by inhalation to 0, 400, 3000 or 8000 ppm MTBE vapor, 6 h a day for 10 weeks prior to mating. Parental animals were then mated within groups for up to 3 weeks. Parental females were exposed during mating, gestation and lactation (starting on day 5); parental males were exposed during mating through delivery of their last litter sired. The F1 adults were selected from the F1 litters and were exposed beginning on postnatal day 28 for at least 8 weeks before mating to produce F2 litters. During exposures to 3000 and 8000 ppm MTBE, group observations included hypoactivity and lack of startle reflex in parental animals from both generations. Parental animals at 8000 ppm were also ataxic. During the pre-mating period, body weights of the 8000 ppm males from both generations and the F1 females were significantly reduced compared to control animals. Transient body weight reduction was also observed in the 3000 ppm F1 males and females during the pre-mating period. Lactational body weights were increased in the 8000 ppm females from both generations. In the F1 generation,...Continue Reading

Citations

May 22, 2003·Reproductive Toxicology·Trish Berger, Catherine M Horner
Jun 24, 2008·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Scott PhillipsAaron Brody
Feb 17, 1998·Risk Analysis : an Official Publication of the Society for Risk Analysis·J J Clary
Dec 19, 2015·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Arastoo SaeediAfshin Mohammadi-Bardbori
May 13, 2014·Regulatory Toxicology and Pharmacology : RTP·Ann de Peyster, Ellen Mihaich
Jul 9, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Arastoo SaeediAfshin Mohammadi-Bardbori
May 31, 2003·Journal of Toxicology and Environmental Health. Part a·Janet M BensonEdward B Barr
Jun 15, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Ann de Peyster
Jul 1, 2006·Critical Reviews in Toxicology·Douglas McGregor
Dec 11, 2019·Environmental Health Perspectives·Lalith K SilvaBenjamin C Blount

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