Two hypothetical nystagmus procedures: augmented tenotomy and reattachment and augmented tendon suture (Sans tenotomy)

Journal of Pediatric Ophthalmology and Strabismus
Louis F Dell'OssoM J Thurtell

Abstract

To review the hypothetical mechanism and therapeutic benefits of the four-muscle tenotomy and reattachment (T&R) procedure using knowledge accrued over the 10 years since its proposal; to describe an augmented tendon suture (ATS) technique to improve the procedure based on one of the originally suggested alternative methods (mechanical); and to hypothesize a new ATS procedure to achieve the same therapeutic benefits without extraocular muscle tenotomy or reattachment to the globe. Standard surgical methods were used. The T&R procedure damps and improves infantile nystagmus syndrome (INS) waveforms, improves eXtended Nystagmus Acuity Function (NAFX) values, broadens the NAFX peak versus gaze angle, and damps slow eye movements but not saccades. The T&R procedure also damps acquired pendular and downbeat nystagmus, decreasing the patients' oscillopsia, and lowers the target acquisition time in INS. The T&R procedure directly affects only the enthesis of the tendon; there is idiosyncratic variation in the distribution of afferent fibers in the tendons. The ATS technique consists of placing several additional sutures in the tendon proximal to the tenotomy. Based on the hypothetical proprioceptive mechanism for the beneficial effect...Continue Reading

References

Mar 1, 1979·Archives of Ophthalmology·L F Dell'Osso, J T Flynn
Jan 13, 1994·The New England Journal of Medicine·G S TintG Salen
Jul 31, 1999·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·L F Dell'OssoJ B Jacobs
Sep 11, 2001·The Journal of Comparative Neurology·J A Büttner-EnneverP D'Ascanio
Apr 19, 2002·Annals of the New York Academy of Sciences·J A Buttner-EnneverG Ugolini
Jun 22, 2002·Documenta Ophthalmologica. Advances in Ophthalmology·L F Dell'Osso, J B Jacobs
Oct 17, 2002·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Richard W HertleMary Alice Crawford
May 1, 1953·The British Journal of Ophthalmology·J R ANDERSON
Apr 1, 1959·The British Journal of Ophthalmology·D PIERSE
Feb 1, 1964·The Journal of Pediatrics·D W SMITHJ M OPITZ
Nov 5, 2003·Ophthalmology·Richard W HertleSusan D Mellow
Aug 18, 2004·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Michael B YangMonte A Del Monte
Dec 24, 2004·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Richard W HertleSusan D Mellow
Dec 5, 2006·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Marc F Greenberg, Zane F Pollard
Dec 26, 2006·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Zhong WangRobert L Tomsak
Feb 7, 2007·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Zhong I WangJonathan B Jacobs
Mar 31, 2007·Nature Neuroscience·Xiaolan WangMichael E Goldberg
Aug 23, 2008·Progress in Brain Research·L F Dell'Osso, Z I Wang

❮ Previous
Next ❯

Citations

Jul 10, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Andrea M SchildAntje Neugebauer
Nov 11, 2011·Current Treatment Options in Neurology·Matthew J Thurtell, R John Leigh
Nov 26, 2010·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Matthew J Thurtell, R John Leigh
Jan 26, 2011·Journal of Pediatric Ophthalmology and Strabismus·Anand KumarRichard W Hertle
Oct 23, 2014·The British Journal of Ophthalmology·Richard W HertleMichael Reed
Jul 23, 2014·Current Opinion in Ophthalmology·Margaret A Greven, Leonard B Nelson
Dec 31, 2010·Current Opinion in Neurology

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annals of the New York Academy of Sciences
Louis F Dell'Osso
Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
R W HertleSusan D Mellow
Annals of the New York Academy of Sciences
Andreas C EberhornJean A Büttner-Ennever
© 2022 Meta ULC. All rights reserved