Two independent type III secretion mechanisms for YopE in Yersinia enterocolitica

Molecular Microbiology
L W ChengOlaf Schneewind

Abstract

Pathogenic Yersinia species escape the infected host's defense mechanisms by targeting cytotoxic Yop proteins into the cytoplasm of macrophages via a type III secretion pathway. Two separate secretion signals contained in YopE were identified, each of which were sufficient but not necessary for the secretion of reporter molecules. One signal is located within the coding sequence of the first 15 amino acids and is sufficient for the secretion of fusion proteins but not required for YopE secretion. The second signal is located downstream at residues 15-100 of YopE and is only recognized by the type III machinery when it is bound to SycE. We propose the existence of two independent mechanisms that allow for the secretion of Yop proteins.

Citations

Jun 30, 2005·Vaccine·Carolin A WiedigIngo B Autenrieth
Mar 7, 2003·FEMS Microbiology Letters·Mario F Feldman, Guy R Cornelis
Apr 29, 2000·Trends in Microbiology·J C Bennett, C Hughes
Oct 25, 2000·Trends in Microbiology·I B Autenrieth, M A Schmidt
Apr 29, 2000·Trends in Microbiology·L W Cheng, O Schneewind
Dec 2, 2000·Microbes and Infection·S Bleves, G R Cornelis
Mar 5, 2003·Current Opinion in Microbiology·Claude ParsotAnne-Laure Page
Aug 14, 1999·Current Opinion in Microbiology·A P Pugsley, T J Silhavy
Feb 27, 1999·Current Opinion in Microbiology·D M Anderson, O Schneewind
Aug 10, 2000·Molecular Microbiology·K J PedersonJ T Barbieri
Jan 3, 2001·Molecular Microbiology·S A LloydH Wolf-Watz
Apr 20, 2001·Molecular Microbiology·G V PlanoF Ferracci
Oct 9, 2002·Molecular Microbiology·Anne-Laure Page, Claude Parsot
Jun 30, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·G R Cornelis
Jul 30, 2005·Science·Melanie M MarketonOlaf Schneewind
Mar 19, 2008·Infection and Immunity·Lauriane E QueneeOlaf Schneewind
Feb 25, 2009·Infection and Immunity·Claire A CorneliusOlaf Schneewind
Jan 30, 2013·Infection and Immunity·Andrew S HouppertMelanie M Marketon
Oct 18, 2000·Infection and Immunity·J B DayG V Plano
Aug 24, 2004·Infection and Immunity·Sonya L Kujat ChoyB Brett Finlay
Feb 12, 2013·Journal of Bacteriology·George S NiemannFred Heffron
Apr 27, 2010·Journal of Bacteriology·Muriel Masi, Cécile Wandersman
Jul 22, 2008·Journal of Bacteriology·Kelly E RiordanOlaf Schneewind
Oct 3, 2006·Journal of Bacteriology·Anthony W MaressoOlaf Schneewind
Dec 31, 2008·Journal of Bacteriology·Hiroyuki Matsumoto, Glenn M Young
Dec 12, 2012·Journal of Bacteriology·Katherine Given LigtenbergOlaf Schneewind
Nov 14, 2000·Journal of Bacteriology·P A BronsteinS I Miller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Respiration

This feed focuses on cellular respiration in bacteria, known as bacterial respiration. Discover the latest research here.