PMID: 9425116Feb 28, 1998Paper

Two invertebrate acetylcholinesterases show activation followed by inhibition with substrate concentration

The Biochemical Journal
V MarcelDidier Fournier

Abstract

In vertebrates there are two cholinesterases, with differences in catalytic behaviour with respect to substrate concentration: butyrylcholinesterase displays an increased activity at low substrate concentrations, whereas acetylcholinesterase displays inhibition by excess substrate. In two invertebrates, Drosophila melanogaster and Caenorhabditis elegans, we found cholinesterases that showed both kinetic complexities: substrate activation at low substrate concentrations followed by inhibition at higher concentrations. These triphasic kinetics can be explained by the presence of two enzymes with different kinetic behaviours or more probably by the existence of a single enzyme regulated by the substrate concentration.

Citations

Aug 13, 1999·Journal of Enzyme Inhibition·J Stojan
Mar 20, 2004·European Journal of Biochemistry·Jure StojanDidier Fournier
Dec 22, 2006·Biochimica Et Biophysica Acta·Patrick MassonLawrence M Schopfer
Nov 1, 2005·Chemico-biological Interactions·Terrone L RosenberryKunisi S Venkatasubban
Dec 19, 2012·The Science of the Total Environment·Cecília M S PereiraMónica J B Amorim
Jul 28, 2013·Ecotoxicology and Environmental Safety·Gabriela Rodríguez-FuentesKaren Luna-Ramírez
Aug 8, 2015·Anais Da Academia Brasileira De Ciências·Brena P TeodorakEmilio L Streck
Jun 10, 2006·The EMBO Journal·Jacques-Philippe ColletierMartin Weik
Sep 9, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carlota Saldanha
Jan 4, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Milena JankowskaMaria Stankiewicz
Sep 21, 2004·Archives of Insect Biochemistry and Physiology·Haim Reuveny, Ephraim Cohen
Mar 30, 2001·The Journal of Biological Chemistry·L BrochierD Fournier
Apr 17, 2008·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·E V Rozengart, N E Basova
Sep 26, 2020·Ecotoxicology and Environmental Safety·Farideh Khan MirzaAli Akbar Meraaten
Jan 29, 2002·Archives of Biochemistry and Biophysics·Marko GolicnikJure Stojan
Sep 17, 2021·International Journal of Environmental Health Research·Homayoon Yazdanshenas, Majid Tafrihi

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