Two isoforms of the RAC-specific guanine nucleotide exchange factor TIAM2 act oppositely on transmission ratio distortion by the mouse t-haplotype

PLoS Genetics
Yves CharronHermann Bauer

Abstract

Transmission ratio distortion (TRD) by the mouse t-haplotype, a variant region on chromosome 17, is a well-studied model of non-Mendelian inheritance. It is characterized by the high transmission ratio (up to 99%) of the t-haplotype from t/+ males to their offspring. TRD is achieved by the exquisite ability of the responder (Tcr) to trigger non-Mendelian inheritance of homologous chromosomes. Several distorters (Tcd1-Tcd4), which act cumulatively, together promote the high transmission ratio of Tcr and the t-haplotype. Molecularly, TRD is brought about by deregulation of Rho signaling pathways via the distorter products, which impair sperm motility, and the t-sperm specific rescue of sperm motility by the responder. The t-sperm thus can reach the egg cells faster than +-sperm and fertilize them. Previously we have shown that the responder function is accomplished by a dominant negative form of sperm motility kinase (SMOKTCR), while the distorter functions are accomplished by the Rho G protein regulators TAGAP, FGD2 and NME3 proposed to function in two oppositely acting pathways. Here we identify the RAC1-specific guanine nucleotide exchange factor TIAM2 as modifier of t-haplotype TRD. Tiam2 is expressed in two isoforms, the ful...Continue Reading

References

May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M F HammerL M Silver
Jan 1, 1993·Methods in Enzymology·R Ramírez-SolisA Bradley
Nov 15, 2001·The Journal of Biological Chemistry·Naoki MatsuoYo-ichi Nabeshima
Dec 4, 2002·Japanese Journal of Cancer Research : Gann·Ching-Ping TsengKelvin Chingchung Tseng
Nov 18, 2003·Annual Review of Genetics·Mary F Lyon
Dec 31, 2003·Developmental Biology·Myrto Raftopoulou, Alan Hall
Oct 27, 2005·The Journal of Biological Chemistry·Angeliki MalliriJohn G Collard
May 8, 2008·FEBS Letters·Francisco M Vega, Anne J Ridley
Nov 11, 2008·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Shin-ichi TerawakiToshio Hakoshima
Nov 7, 2009·The EMBO Journal·Shin-ichi TerawakiToshio Hakoshima
Apr 7, 2011·International Journal of Cancer. Journal International Du Cancer·Jia-Shing ChenH Sunny Sun
Jan 1, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Zheng-Yuan ZhaoLi-Ya Cheng
Jun 24, 2014·Molecular Genetics and Genomics : MGG·Zu-Kang GongWen-Zhen Lin
Mar 1, 2006·Journal of Chemical Theory and Computation·Alexander V NemukhinStanley K Burt

❮ Previous
Next ❯

Citations

Nov 14, 2019·Proceedings. Biological Sciences·Anna LindholmHubert Rehrauer
Oct 24, 2020·The CRISPR Journal·Chandran PfitznerPaul Q Thomas
Jan 16, 2021·Cellular and Molecular Life Sciences : CMLS·Alyssa N Kruger, Jacob L Mueller
Feb 5, 2021·PLoS Genetics·Alexandra Amaral, Bernhard G Herrmann

❮ Previous
Next ❯

Datasets Mentioned

BETA
3033374

Methods Mentioned

BETA
GTPase
nucleotide exchange
transgenic
PCR
GTPases
electrophoresis
CAGE-Seq
transfection
transgenics

Software Mentioned

Primer3

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.