Two kinds of items in quality of life instruments: 'indicator and causal variables' in the EORTC qlq-c30

Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation
Sonja Boehmer, Aleksandra Luszczynska

Abstract

Two kinds of variables may be differentiated within instruments measuring health-related quality of life (HRQOL). Physical symptoms may be called causal variables because their occurrence can cause a change in HRQOL, but poor HRQOL need not necessarily imply that a patient suffers from these symptoms. Other items can be regarded as indicator variables. They reflect the level of HRQOL and a patient with a poor HRQOL is likely to have low scores on all indicator variables. The aim of this study was to test the relationship of the latent HRQOL construct to items and domains on the EORTC QLQ-C30. Confirmatory factor analysis was performed on EORTC QLQ-C30 data from 205 gastrointestinal cancer patients assessed one month after surgery. Functioning scales were established as variables indicating the level of HRQOL whereas all other subscales and items were established as variables causing a change in HRQOL. The model-data fit was satisfactory. Results support the hypothesis that two kinds of variables may be differentiated within HRQOL instruments. Further research should investigate whether both kinds of variables could be combined into a higher order, aggregate score for HRQOL.

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Citations

Feb 3, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Andrea LiekwegUlrich Jaehde
Dec 22, 2011·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Chad M GundyNeil K Aaronson
Apr 2, 2013·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Ellen M Lavoie SmithCharles L Loprinzi
Oct 14, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ana Claudia Garabeli Cavalli KluthcovskySergio Bruno Bonatto Hatschbach
Sep 4, 2015·Journal of Clinical Epidemiology·Johannes M GiesingerUNKNOWN EORTC Quality of Life Group
Jul 27, 2010·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chi-Cheng HuangWei-Chu Chie
Mar 25, 2008·Journal of Clinical Epidemiology·Neil W ScottUNKNOWN Quality of Life Cross-Cultural Meta-Analysis Group
Oct 26, 2012·Psycho-oncology·Aleksandra LuszczynskaUrte Scholz
Feb 4, 2012·Statistics in Medicine·Annette KifleyVal Gebski
Sep 17, 2013·Statistics in Medicine·Niels Smits, Matthew D Finkelman
Mar 3, 2015·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Daniel S J Costa
Feb 13, 2015·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Jorge M Estrada ÁlvarezEdwin Moreno Rojas
Jan 7, 2015·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Chi-Cheng HuangWei-Chu Chie
Jul 10, 2014·Journal of the National Cancer Institute·Carolyn Gotay
May 7, 2013·Surgical Neurology International·Lisa B E ShieldsAli K Choucair
Nov 30, 2019·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Kathrin SommerFabio Efficace
Jan 8, 2021·Health and Quality of Life Outcomes·Silvia TestaRosalba Rosato

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