Two macrophage colony-stimulating factor genes exist in fish that differ in gene organization and are differentially expressed

The Journal of Immunology : Official Journal of the American Association of Immunologists
Tiehui WangChristopher J Secombes

Abstract

Mammalian macrophage CSF (MCSF; CSF-1) is the primary regulator of the mononuclear phagocyte lineage. We, for the first time, report the complete sequencing of five MCSF cDNAs from three fish species, rainbow trout, zebrafish, and goldfish. Despite the difference in the lengths of the MCSF transcripts, all of the fish MCSF molecules encode a signal peptide, a CSF-1 domain, a transmembrane domain, and an intracellular region. Each fish MCSF gene has a unique exon/intron structure. The primordial MCSF gene may have had a nine exon/eight intron structure. In this model, insertion of an intron in exon 6 in primitive fish created the fish type I MCSF, while the loss of this exon or part of the original exon 6 created the fish type II MCSF. Investigation of alternative splicing variants in trout suggests that no mammalian equivalent splice variants exist. The two trout MCSF genes are differentially expressed in vivo and contributed differently to the high-level expression of MCSF in spleen and head kidney. In contrast to the up-regulation of MCSF by PMA in mammals, in trout MCSF1 expression is down-regulated by PMA treatment. As in mammals, recombinant trout MCSF1 can promote the growth of head kidney leukocytes, and it up-regulates ...Continue Reading

References

Jan 1, 1997·Molecular Reproduction and Development·M HarringtonA Song
Jan 1, 1997·Molecular Reproduction and Development·L R RohrschneiderK Carlberg
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Mar 17, 1998·Cytokine·P Fixe, V Praloran
May 18, 2001·Developmental and Comparative Immunology·J L StaffordM Belosevic
Oct 29, 2002·Cytokine & Growth Factor Reviews·Steve BirdChris J Secombes
Sep 11, 2003·Molecular & Cellular Proteomics : MCP·Yee-Guide Yeung, E Richard Stanley
Mar 23, 1962·Science·K WOLF, M C QUIMBY
Jun 30, 2004·Journal of Molecular Biology·Jannick Dyrløv BendtsenSøren Brunak
Nov 3, 2004·Trends in Cell Biology·Fiona J Pixley, E Richard Stanley
Jun 7, 2005·Fish & Shellfish Immunology·Miodrag BelosevicDaniel R Barreda
Jun 28, 2005·Developmental and Comparative Immunology·Daniel R BarredaMiodrag Belosevic
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jun ZouChris Secombes
Aug 30, 2005·Current Topics in Developmental Biology·Liping LiuRichard M Ransohoff
Dec 13, 2005·Current Opinion in Immunology·Violeta Chitu, E Richard Stanley
Dec 31, 2005·Nucleic Acids Research·Ivica LetunicPeer Bork
Aug 1, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Katharine M IrvineMatthew J Sweet
Oct 19, 2006·Journal of Leukocyte Biology·Clemens GrabherJoachim Wittbrodt
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tiehui WangChristopher J Secombes
Sep 11, 2007·The Journal of Biological Chemistry·Patrick C HaningtonMiodrag Belosevic

❮ Previous
Next ❯

Citations

Oct 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Narges AghaallaeiThomas Boehm
Jun 26, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tiehui WangChristopher J Secombes
Sep 29, 2017·Frontiers in Immunology·Brian K LohmanDaniel I Bolnick
Jun 13, 2018·Frontiers in Immunology·Leon GrayferMiodrag Belosevic
Dec 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tiehui WangChristopher J Secombes
Dec 4, 2015·Biology·Jordan W HodgkinsonMiodrag Belosevic
May 28, 2016·Biology·Jun Zou, Christopher J Secombes
Jan 5, 2019·Current Pharmaceutical Design·Thea MagroneEmilio Jirillo
Aug 12, 2020·Scientific Reports·Annelieke S WentzelGeert F Wiegertjes
Dec 29, 2011·Journal of Signal Transduction·Tiehui WangChristopher J Secombes
Nov 19, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Suhee HongTiehui Wang
May 30, 2014·Blood·Ondřej SvobodaPetr Bartůněk
Feb 16, 2019·Growth Factors·Vahid Pazhakh, Graham J Lieschke
Dec 21, 2017·The Journal of Biological Chemistry·Amulya YaparlaLeon Grayfer
Jan 9, 2019·Frontiers in Cell and Developmental Biology·Jana OltovaPetr Bartunek
Dec 26, 2015·Developmental and Comparative Immunology·Leon Grayfer, Jacques Robert
Dec 25, 2012·Developmental and Comparative Immunology·Aja M RiegerDaniel R Barreda
Apr 19, 2017·Developmental and Comparative Immunology·Gregory JacobsonSteve Bird
Dec 10, 2008·Developmental and Comparative Immunology·Patrick C HaningtonMiodrag Belosevic
Dec 21, 2011·Developmental and Comparative Immunology·Lieke M van der AaB M Lidy Verburg-van Kemenade
Oct 10, 2020·Drug Discovery Today·Rodrigo ZanandreaMaria M Campos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.