PMID: 59154Jul 10, 1976

Two mechanisms for hypothyroidism after 131I therapy

J F Malone, M J Cullen


It is proposed that the incidence of hypothyroidism after radioiodine therapy of thyrotoxicosis has two distinct mechanism. One operates in the first two years after therapy and depends on radiation dose. The other operates in later years, and is not, to any significant extent, dose dependent. Possible canidates for each mechanism are explored.


Aug 11, 1973·Lancet·W F BremnerW R Greig
Nov 12, 1964·The New England Journal of Medicine·J T DUNN, E M CHAPMAN


Jun 16, 2004·Annals of Nuclear Medicine·Tamotsu KitaNorihisa Tonami
Feb 1, 1989·Epidemiology and Infection·A M LewisS Tabaqchali
Jun 1, 1978·The British Journal of Radiology·M K O'Connor, J F Malone
Feb 1, 1995·Thyroid : Official Journal of the American Thyroid Association·A W KungA C Cheng
Sep 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·A M Josephson, T B Mackenzie
Jul 1, 1980·The British Journal of Ophthalmology·R S Bartholomew, M Macdonald
Jun 1, 1995·Thyroid : Official Journal of the American Thyroid Association·V P MichelangeliP G Colman
Sep 26, 2001·BMC Nuclear Medicine·Suhail AR DoiKamal AS Al-Shoumer
Jun 1, 1992·The Journal of International Medical Research·A ZainiB H Khoo
Oct 10, 2020·Journal of Neural Transmission·Christoph ReinersShunichi Yamashita

Related Concepts

Dose-Response Relationship, Radiation
Iodine Radioisotopes
Effects of Radiation
Radiotherapy Dosage
Thyroid Gland

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.