Two medium-chain acyl-coenzyme A synthetase genes, SAH and MACS1, are associated with plasma high-density lipoprotein cholesterol levels, but they are not associated with essential hypertension

Journal of Hypertension
Akira HaketaKoichi Matsumoto

Abstract

SAH has been proposed as a candidate gene for essential hypertension (EH) because elevated expression of SAH was observed in the kidneys of spontaneously hypertensive rats. Recently, a homology search of SAH in the human genome revealed the presence of the SAH gene family, which includes SAH, MACS1, MACS2, and MACS3. SAH and MACS1 are located within a 150-kb region on human chromosome 16p13.11. SAH and MACS1 are thought to function as acyl-coenzyme A synthetases, which are involved in fatty acid metabolism. In the present study, we analyzed six single nucleotide polymorphisms (SNPs) in the SAH and MACS1 genes in a Japanese population, and examined whether these SNPs contribute to EH and multiple risk factors. We performed association studies of six SNPs in 287 EH patients and 259 normotensive subjects. Multiple logistic linear regression analysis revealed that the allele frequencies of these six SNPs in SAH and MACS1 genes were not significantly different between EH patients and normotensives. SNP in exon 8 of the A/G polymorphism of the MACS1 gene and the G/T SNP in intron 3 of the SAH gene were associated with plasma levels of plasma high-density lipoprotein cholesterol. SNPs in the MACS1 and SAH genes contribute to plasma le...Continue Reading

References

Mar 15, 1994·Biochemical and Biophysical Research Communications·N J SamaniD Lodwick
Jul 12, 1996·The Journal of Biological Chemistry·T FujinoT Yamamoto
Jun 1, 1968·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·W G Hill, A Robertson

❮ Previous
Next ❯

Citations

Apr 6, 2005·Trends in Endocrinology and Metabolism : TEM·Anupam AgarwalNaomi D L Fisher
Mar 6, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yu JinUNKNOWN European Project on Genes in Hypertension (EPOGH) Investigators
Mar 25, 2010·Molecular & Cellular Proteomics : MCP·Isabel BaigesLluís Arola
Oct 3, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Zhao Xia WangShigeaki Hinohara
Oct 24, 2009·Endocrine Journal·Tomohiro Nakayama, Tatsuo Yamamoto
Feb 7, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Wenjin LiYongyong Shi
Mar 23, 2011·Clinical Biochemistry·Ken MatsumotoNoriko Aoi
Feb 27, 2010·Journal of Psychiatric Research·Lavinia AthanasiuOle A Andreassen
Feb 27, 2010·American Journal of Hypertension·Masanori ShimodairaKoichi Matsumoto
Feb 28, 2008·Journal of Hypertension·Zhenyan FuYitong Ma
Jan 15, 2008·Journal of Hypertension·Valérie TikhonoffUNKNOWN European Project On Genes in Hypertension (EPOGH) investigators
May 30, 2020·Prenatal Diagnosis·Toluwani E TaiwoRichard H Finnell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.