PMID: 3133658Jul 1, 1988

Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells

Proceedings of the National Academy of Sciences of the United States of America
P LemaireP Charnay

Abstract

We previously reported the identification of a mouse gene, Krox-20, encoding a protein with three "zinc fingers" (DNA-binding domains with coordinated zinc ions) whose expression is regulated during G0/G1 transition (cell-cycle reentry). We now have isolated cDNAs corresponding to a related gene, Krox-24. Krox-24 encodes a protein with zinc fingers nearly identical to those encoded by Krox-20 and similar to those of transcription factor Sp1. Similarity between Krox-20 and Krox-24 proteins also extends to several blocks of amino acid sequence located upstream of the finger region. Like Krox-20, Krox-24 is transiently activated in quiescent cells after treatment with fetal bovine serum or purified growth factors. The kinetics of activation are similar to those of the protooncogene c-fos. The induction does not require de novo protein synthesis, and cycloheximide treatment of the cells leads to superinduction due, at least in part, to mRNA stabilization. In the mouse, the two genes are expressed in a tissue-specific manner, with slightly different patterns. These properties suggest that Krox-20 and Krox-24 may encode transcription factors with identical DNA target sequences and that these factors may be involved in the modulation ...Continue Reading

References

Apr 29, 1998·The Journal of Comparative Neurology·C V Mello, S Ribeiro
Nov 2, 2004·Journal of Cellular Biochemistry·Hirohiko OkamuraTatsuji Haneji
Nov 4, 2004·Journal of Cellular Biochemistry·Alia Al-SarrajGerald Thiel
Dec 1, 1994·Journal of Cellular Biochemistry·R P HuangE D Adamson
Oct 18, 2002·Journal of Cellular Physiology·Gerald Thiel, Giuseppe Cibelli
Jul 1, 1991·Journal of Cellular Physiology·D E Epner, H R Herschman
Aug 1, 1993·Molecular Reproduction and Development·P HolthuizenJ S Sussenbach
Apr 1, 1994·Neurochemical Research·D F CondorelliA M Giuffrida-Stella
Jan 1, 1991·Molecular Neurobiology·W C AbrahamW Tate
May 3, 2011·Calcified Tissue International·Marie K ReumannPhilipp Mayer-Kuckuk
Oct 4, 2011·Current Treatment Options in Oncology·Eric PadronAlan F List
Jan 1, 1990·Pharmacology & Therapeutics·H J Rahmsdorf, P Herrlich
Jul 1, 1995·Brain Research. Brain Research Reviews·M Dragunow, K Preston
Apr 1, 1992·Brain Research. Molecular Brain Research·R V BhatJ M Baraban
Mar 1, 1992·Brain Research. Molecular Brain Research·C MathenyJ Milbrandt
Jan 1, 1992·Brain Research. Molecular Brain Research·M A McCormackG D Mower
May 1, 1992·Brain Research. Molecular Brain Research·P HughesM Dragunow
May 1, 1993·Brain Research. Molecular Brain Research·S R Abu-ShakraD B Drachman
Jan 1, 1995·Brain Research. Molecular Brain Research·J WilliamsW Tate
Jan 3, 1994·Neuroscience Letters·J HermsK H Schlingensiepen

Citations

Jan 1, 1978·Annual Review of Biochemistry·A B PardeeR F Kletzien
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J L CordenM E Dahmus
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M RaymondjeanM Yaniv
Sep 11, 1987·Cell·A DornD Mathis
Jan 11, 1984·Nucleic Acids Research·J DevereuxO Smithies

Related Concepts

Early Growth Response Protein 2
Immediate-Early Proteins
Interphase
Proteins, Recombinant DNA
Tissue Specificity
Fos
Egr2
Metalloproteins
Growth Substances
Sp1

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.