PMID: 15387145Sep 25, 2004Paper

Two-mutation models for bone cancer due to radium, strontium and plutonium

Radiation Research
H BijwaardH P Leenhouts

Abstract

Data from beagle experiments and radium dial painters were used to derive two-mutation carcinogenesis models for bone cancer induced by the bone-seeking radionuclides radium, strontium and plutonium. For all data, the model fits indicate that at low doses both mutation rates depend linearly and equally strongly on dose rate. For the high-LET alpha-particle emitters, a cell killing term reduces the second mutation rate at high dose rates. In all cases, the combined effect of both mutation rates is a linear-quadratic dose-effect relationship for cancer at low doses. This behavior may lead to experimental data that could be mistaken as showing a threshold below which no cancers are induced. Derived parameters such as toxicity ratios and tumor growth times compare well with values reported in the literature. Furthermore, results for plutonium indicate that rapid burial of the nuclide in the growing bones of juvenile beagles leads to a significant reduction of its toxicity, as was suggested previously. The results for radium in beagles compare well with those for humans and suggest that the models derived for strontium and plutonium in beagles may be translated to humans. The significant model parameters for the accurate animal data...Continue Reading

References

May 1, 1990·International Journal of Radiation Biology·O G RaabeR A Schlenker
Jun 1, 1990·Risk Analysis : an Official Publication of the Society for Risk Analysis·S H Moolgavkar, G Luebeck
Jan 1, 1987·Acta Oncologica·A Nilsson, S A Book
Jan 1, 1993·Health Physics·R D LloydS C Miller
Jan 1, 1997·Health Physics·R D LloydW S Jee
Jul 6, 2000·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·H P Leenhouts, M J Brugmans
Aug 24, 2000·Radiation Research·N A KoshurnikovaV V Vostrotin
Apr 3, 2001·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·K H Chadwick
Dec 1, 2001·Health Physics·R D LloydW S Jee
Feb 1, 2002·Radiation and Environmental Biophysics·H BijwaardH P Leenhouts
May 17, 2002·Radiation and Environmental Biophysics·A M Kellerer
May 17, 2002·Radiation and Environmental Biophysics·N A KoshurnikovaS A Romanov
Oct 29, 2002·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·H BijwaardH P Leenhouts
Oct 29, 2002·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Marco J P BrugmansHenk P Leenhouts
Sep 19, 2003·Journal of Radiation Research·Yoichi Oghiso, Yutaka Yamada
Dec 26, 2003·Health Physics·E PoligS C Miller
Oct 1, 1933·American Journal of Public Health and the Nation's Health·R D Evans

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Citations

May 3, 2005·Radiation and Environmental Biophysics·W F HeidenreichM Rosemann
Mar 11, 2015·Radiation Protection Dosimetry·W RühmC Woda
Jun 13, 2015·International Journal of Radiation Biology·Otto G Raabe
Jul 20, 2016·The Science of the Total Environment·A Walencik-ŁataT A Przylibski
Nov 2, 2007·Radiation Research·Harmen Bijwaard, Fieke Dekkers

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