Two MYB Proteins in a Self-Organizing Activator-Inhibitor System Produce Spotted Pigmentation Patterns.

Current Biology : CB
Baoqing DingYao-Wu Yuan

Abstract

Many organisms exhibit visually striking spotted or striped pigmentation patterns. Developmental models predict that such spatial patterns can form when a local autocatalytic feedback loop and a long-range inhibitory feedback loop interact. At its simplest, this self-organizing network only requires one self-activating activator that also activates a repressor, which inhibits the activator and diffuses to neighboring cells. However, the molecular activators and inhibitors fully fitting this versatile model remain elusive in pigmentation systems. Here, we characterize an R2R3-MYB activator and an R3-MYB repressor in monkeyflowers (Mimulus). Through experimental perturbation and mathematical modeling, we demonstrate that the properties of these two proteins correspond to an activator-inhibitor pair in a two-component, reaction-diffusion system, explaining the formation of dispersed anthocyanin spots in monkeyflower petals. Notably, disrupting this pattern impacts pollinator visitation. Thus, subtle changes in simple activator-inhibitor systems are likely essential contributors to the evolution of the remarkable diversity of pigmentation patterns in flowers.

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Citations

May 16, 2020·The Plant Journal : for Cell and Molecular Biology·Monica Borghi, Alisdair R Fernie
Oct 18, 2020·International Journal of Molecular Sciences·Jack ColicchioLena Hileman
Dec 17, 2020·Journal of Integrative Plant Biology·Nai-Qian Dong, Hong-Xuan Lin
Mar 11, 2020·Current Biology : CB·Murat Ünalan, Patrick Müller
Apr 11, 2021·The Plant Journal : for Cell and Molecular Biology·Oded SkaliterAlexander Vainstein
Apr 27, 2021·Frontiers in Plant Science·Sarita Muñoz-GómezNatalia Pabón-Mora
May 7, 2021·Biological Reviews of the Cambridge Philosophical Society·Pierre GalipotFlorian Jabbour
Apr 18, 2021·The New Phytologist·Amy M LaFountain, Yao-Wu Yuan

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