Two new antiprotozoal 5-methylcoumarins from Vernonia brachycalyx

Journal of Natural Products
H A Oketch-RabahS B Christensen

Abstract

Two new isomeric 5-methylcoumarins, 2'-epicycloisobrachycoumarinone epoxide (1) and cycloisobrachycoumarinone epoxide (2), have been isolated from the roots of Vernonia brachycalyx by means of bioactivity-guided fractionation. The structures were elucidated by MS and NMR spectroscopic methods. Compounds 1 and 2 showed in vitro activity against Leishmania major promastigotes and against Plasmodium falciparum schizonts and demonstrated an inhibition on the proliferation of human lymphocytes, which was significantly weaker than the antiparasitic effects.

Citations

Nov 15, 2000·Fitoterapia·H A Oketch-RabahE K Mberu
Sep 7, 2001·Fitoterapia·P B de Carvalho, E I Ferreira
Aug 23, 2002·Contact Dermatitis·Anna Belloni FortinaAndrea Peserico
Jan 2, 2016·Journal of Ethnopharmacology·Leonidah K OmosaThomas Efferth
Feb 12, 2013·Journal of Ethnopharmacology·Ngeh J Toyang, Rob Verpoorte
Oct 2, 2007·Journal of Ethnopharmacology·C N MuthauraE N M Njagi
Jul 13, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·L G RochaJ M Barbosa-Filho
Jun 4, 2014·Journal of Ethnopharmacology·Ghulam Mujtaba ShahAdnan Ahmad Tahir
Aug 6, 2016·European Journal of Medicinal Chemistry·Marta CostaFernanda Proença
Oct 22, 2016·PloS One·Vineetha MandlikShailza Singh
Jan 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Peter Mubanga CheukaKelly Chibale
Mar 13, 2018·Parasite : Journal De La Société Française De Parasitologie·Sujogya Kumar Panda, Walter Luyten
Feb 26, 2003·Phytotherapy Research : PTR·Carola KraftEckart Eich
Nov 26, 2009·Natural Product Reports·Joseph J Magadula, Paul Erasto
Jul 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Taieb TounektiHabib Khemira
Dec 1, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Renata Mondêgo-OliveiraAna Lucia Abreu-Silva
Nov 17, 2001·Phytochemistry·Sami A. KhalidS Brøgger Christensen

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