Two new bis-C20 -diterpenoid alkaloids with anti-inflammation activity from Aconitum bulleyanum

Journal of Asian Natural Products Research
Xiao-Yan DuanYong Shen

Abstract

Two new bis-C20-diterpenoid alkaloids, bulleyanines A and B (1 and 2), were isolated from Aconitum bulleyanum. Their structures were elucidated by comprehensive spectroscopic analyses including UV, IR, MS, 1D and 2D NMR. Biological activity tests indicated that compound 1 exhibited significant inhibitory activity against nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW264.7 macrophages with the inhibition rate of 74.60% (40 μmol/L), while positive control dexamethasone gave 78.70% inhibition at 100 μg/ml.

References

Oct 16, 2009·The Alkaloids. Chemistry and Biology·Feng-Peng WangXiao-Tian Liang

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Citations

Nov 8, 2020·Journal of Pharmaceutical and Biomedical Analysis·Ling-Li ChenLu-Qi Huang

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Methods Mentioned

BETA
NMR
column chromatography

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