Two new Cu(II)-based coordination polymers: inhibitory activity on prostate cancer by reducing EGF-R expression and HIPPO signaling pathway activation.

Journal of Biomaterials Science. Polymer Edition
Xiang-Ying WangHui-Qing Ma

Abstract

Under solvothermal conditions, two new coordination polymers (CPs), namely {[Cu(HL)]·2CH3CN}n (1) and {[Cu(HL)(bimb)]·4H2O}n (2) (H3L = tris(p-carboxyphenyl)phosphane oxide, bimb = 1,4-bis(imidazol-1-ylmethyl)benzene) were prepared. Their treatment activity on the human prostate cancer was evaluated through series of biological experiments. Firstly, the human prostate cancer cells proliferation was determined with Cell Counting Kit-8 (CCK-8) detection kit. The influence of compounds 1 and 2 on the cancer cells migration and invasion ability was measured with trans-well assay. Next, the important role of the EGF-R human prostate cancer cells was determined with western blotting. In the end, the activation of the HIPPO signaling pathway was detected with real-time reverse transcription polymerase chain reaction (RT-PCR).

References

Dec 27, 2005·Gene·Nicola NormannoDavid S Salomon
Apr 23, 2009·Chemical Society Reviews·Alexander M SpokoynyChad A Mirkin
Jun 6, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Xun FengBei Ya Su
Oct 11, 2015·Journal of the American Society of Nephrology : JASN·Jianchun Chen, Raymond C Harris
Sep 9, 2016·The Prostate·Cachétne S X BarrettShafiq A Khan
Aug 10, 2017·Methods in Molecular Biology·Zhixiang Wang
Oct 11, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Xun FengLiya Wang

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Methods Mentioned

BETA
X-ray
light microscopy
Protein
electrophoresis

Software Mentioned

SHELXS
AFIX
SHELXL
CrysAlisPro

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