Two new echinocystic acid derivatives catalyzed by filamentous fungus Gliocladium roseum CGMCC 3.3657

Natural Product Research
Shao-Bin FuDi-An Sun

Abstract

Biotransformation of Echinocystic acid (EA,1) using G. roseum CGMCC 3.3657 has been investigated, which leads to the isolation and identification of two novel Echinocystic acid derivatives, 4, 16α-dihydroxy-3,4-seco-olean-12-en-3,28-dioic acid (2) and 16α-hydroxy, A-homo-3α-oxa-olean-12-en-3-one-28-oic acid (3). Their structures have been elucidated by analysis of spectroscopic data. This biocatalysis could serve as an efficient tool complementary to classical chemical methods for the transformation of EA.

References

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Jul 3, 2007·Chemical & Pharmaceutical Bulletin·Fang LiKazuo Koike
Aug 15, 2009·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Xue-Feng ZhouJi-Zhou Wu
May 7, 2013·European Journal of Medicinal Chemistry·Han WangDe-Min Zhou
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Aug 5, 2017·Bioresources and Bioprocessing·Hongchang YuYulian Zhan

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Citations

Mar 3, 2020·Journal of Applied Microbiology·Z-B SunM-H Sun

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Methods Mentioned

BETA
gel column chromatography
coronary artery dilation
NMR

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