PMID: 9194157Apr 1, 1997Paper

Two new examples of protein structural similarities within the structure-function twilight zone

Protein Engineering
R B Russell, M J Sternberg

Abstract

Two three-dimensional protein structural similarities accompanied by slight similarities in function are reported to highlight the present difficulties in discerning the relationship between structure and function. The similarity between the structures of uteroglobin and the CAP domain of haloalkane dehalogenase reveals a common four helix hydrophobic ligand binding motif. The similarity between the beta-barrel domains of glutaminyl tRNA synthetase and domain 1 of glutamine synthetase is accompanied by some similarity in the location of nucleotide binding sites and suggests a possible ancient domain common to these two proteins involved in the synthesis or binding of glutaminyl moieties. The problems raised by these two similarities in the structure-function 'twilight zone' are discussed.

Citations

Apr 6, 2004·Current Opinion in Chemical Biology·Dick B Janssen
Apr 23, 2002·Protein Science : a Publication of the Protein Society·Michal Otyepka, Jirí Damborský
May 28, 2010·BMC Structural Biology·Todd J Taylor, Iosif I Vaisman
Feb 14, 2007·Proteins·Eva ChovancováJirí Damborský
Jun 11, 1999·Current Opinion in Structural Biology·C A OrengoJ M Thornton
Sep 23, 1998·Journal of Molecular Biology·R B RussellM J Sternberg
May 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Thiau-Fu AngThean Chor Leow
Sep 28, 2017·Journal of Biomolecular Structure & Dynamics·Andrea AmadeiMarco D'Abramo
Jan 19, 2007·Molecular Pharmacology·David HamiltonGerald Batist
Sep 1, 2007·Integrative and Comparative Biology·K Ravi Ram, Mariana F Wolfner
Feb 24, 2001·Annals of the New York Academy of Sciences·I CallebautJ P Mornon

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