Two New Furanoeremophilanes from Senecio santelisis

Chemistry & Biodiversity
María L Arias CassaráMaría I Ybarra

Abstract

From an Argentine collection of Senecio santelisis Phil., the new furanoeremophilanoids, (10betaH)-6beta-acetoxy-1alpha-hydroxyfuranoeremophilan-9-one (1) and (10betaH)-1alpha-hydroxy-6beta-(propanoyloxy)furanoeremophilan-9-one (2), together with the known (10alphaH)-6beta-acetoxy-1alpha-hydroxyfuranoeremophilan-9-one (3), (10alphaH)-1alpha,6beta-diacetoxyfuranoeremophilan-9-one (4), and (10alphaH)-1alpha-hydroxy-6beta-(propanoyloxy)furanoeremophilan-9-one (5) were isolated. Their structures and relative configurations were established on the basis of spectroscopic analysis. CHCl3 Extract and pure compounds were evaluated for their antifungal activity. Compound 5 exhibited remarkable mycelial growth inhibition against B. cinerea with an IC(50) value of 21.4 microg/ml.

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Citations

May 8, 2013·The Journal of Organic Chemistry·Ana L SilvaLuis A Maldonado
Aug 3, 2011·Natural Product Reports·Braulio M Fraga
Mar 17, 2012·Chemistry & Biodiversity·Matías ReinaAzucena González-Coloma
Jan 31, 2017·Chemistry & Biodiversity·María de Los A MesuradoElena Cartagena
Jun 19, 2019·Plants·Liliana Ruiz-VásquezAzucena González-Coloma

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