Two new monoterpene glycosides from ku-ding-cha. Inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT)

Chemical & Pharmaceutical Bulletin
T FukudaToshio Miyase

Abstract

Two new monoterpene glycosides, kudingosides A and B, were isolated from Ku-Ding-Cha (Ligustrum pedunculare REHD.), together with a known monoterpene glycoside, (S)-lipedoside B-III, and three known phenylethanoid glycosides. Their structures were elucidated by spectroscopic and chemical means. Kudingosides A and B, and (S)-lipedoside B-III inhibited acyl-CoA: cholesterol acyltransferase (ACAT) with IC50 values of 2.70 x 10(-3)M, 2.88 x 10(-3)M, and 2.69 x 10(-4)M, respectively.

Citations

Apr 13, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hideyuki ItoYoshitaka Takahashi
Jun 20, 2001·Chemical & Pharmaceutical Bulletin·Z D HeH D Sun
Jun 28, 2003·Journal of Natural Products·Zhen-Dan HeHan-Dong Sun

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