Two new neo-clerodane diterpenoids from Scutellaria barbata

Journal of Integrative Plant Biology
Sheng-Jun DaiYan Ren

Abstract

Two new neo-clerodane diterpenoids, 6,7-dibenzoyloxybarbatin C (1, named barbatin D) and 6-(2-acetoxy-3-methylbutanoloxy)-7-(2-carbonyl-3-methylbutanoyloxy) barbatin C (2, named barbatin E) were isolated from the whole plant of Scutellaria barbata D. Don. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR analyses. In vitro, compounds 1-2 showed cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC(50) values in the range of 3.5-6.7 microM.

Citations

Jul 20, 2016·Natural Product Reports·Rongtao LiKuo-Hsiung Lee
Feb 9, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gang WangJi-Kai Liu
Jul 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Samira EghbaliFerizZahra Tayarani-Najaran

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