Two new sesquiterpenes from the stems of Miliusa velutina.

Natural Product Research
Truong Van Nguyen ThienQuang Ton That

Abstract

From the ethyl acetate extract of the stems of Miliusa velutina, seven compounds (1-7) were isolated, including two new compounds such as mivelutina A acid (1), mivelutina B acid (2) and one known compound mivelutina B methyl ester (3). For this NMR data were not known previously. Their relative structures were elucidated based on NMR spectroscopic analysis. The absolute configuartions were determined based on DFT calculations of 13C chemical shifts. All of the seven compounds were screened for their in vitro cytotoxic activities against HepG2 cell line using the SRB assay. Epoxyconiferyl alcohol (7) showed the highest potential for the cytotoxicity of cancer cell lines HepG2 with the IC50 values of 95.94 μg/mL (527 μM).

References

Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
Sep 15, 1988·Physical Review A: General Physics·A D Becke
Mar 22, 2000·Biochemical Systematics and Ecology·S JumanaM A Rashid
Jul 14, 2001·Fitoterapia·S JumanaM A Rashid
Jul 1, 2011·Phytochemistry·Nikhom WongsaKwanjai Kanokmedhakul
Feb 11, 2014·European Journal of Medicinal Chemistry·Yogesh YadavMaged Henary
Aug 31, 2016·Fitoterapia·Ratchanee PhatchanaChavi Yenjai

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