Two New SGI1-LK Variants Found in Proteus mirabilis and Evolution of the SGI1-HKL Group of Salmonella Genomic Islands.

MSphere
Claire de CurraizeRuth M Hall

Abstract

Integrative mobilizable elements belonging to the SGI1-H, -K, and -L Salmonella genomic island 1 (SGI1) variant groups are distinguished by the presence of an alteration in the backbone (IS1359 replaces 2.8 kb of the backbone extending from within traN [S005] to within S009). Members of this SGI1-HKL group have been found in Salmonella enterica serovars and in Proteus mirabilis Two novel variants from this group, designated SGI1-LK1 and SGI1-LK2, were found in the draft genomes of antibiotic-resistant P. mirabilis isolates from two French hospitals. Both variants can be derived from SGI1-PmGUE, a configuration found previously in another P. mirabilis isolate from France. SGI1-LK1 could arise via an IS26-mediated inversion in the complex class 1 integron that duplicated the IS26 element and the target site in IS6100 SGI1-LK1 also has a larger 8.59-kb backbone deletion extending from traN to within S013 and removing traG and traH. However, SGI1-LK1 was mobilized by an IncC plasmid. SGI1-LK2 can be derived from a hypothetical progenitor, SGI1-LK0, that is related to SGI1-PmGUE but lacks the aphA1 gene and one copy of IS26. The integron of SGI1-LK2 could arise via deletion of DNA adjacent to an IS26 and a deletion occurring via hom...Continue Reading

References

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Sep 7, 2014·The Journal of Antimicrobial Chemotherapy·Mohammad HamidianRuth M Hall
Apr 29, 2015·Antimicrobial Agents and Chemotherapy·Chang-Wei LeiYong-Qiang Yang
Jun 16, 2016·MSphere·Christopher J Harmer, Ruth M Hall
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May 21, 2019·Microbial Genomics·Jane HawkeyFrançois-Xavier Weill
Jun 6, 2019·Microbial Genomics·Jaspreet MahindrooNeelam Taneja

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Datasets Mentioned

BETA
MH734354
MN167852
AF261825
AM942759
JX121639
AY463797
LT630458
JX121641
MG764534
EA409

Methods Mentioned

BETA
PCR
PCRs

Software Mentioned

ResFinder
BLAST
Basic Local Alignment Search Tool ( BLAST )

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