Two Novel Aspochalasins from the Gut Fungus Aspergillus sp. Z4

Marine Drugs
Xinyang LiJinzhong Xu

Abstract

Two novel aspochalasins, tricochalasin A (1) and aspochalasin A2 (2), along with three known compounds (3⁻5) have been isolated from the different culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. Compound 1 contains a rare 5/6/6 tricyclic ring fused with the aspochalasin skeleton. The structures were determined on the basis of electrospray ionisation mass spectroscopy (ESIMS), nuclear magnetic resonance (NMR) spectral data, and the absolute configurations were further confirmed by modified Mosher's method. Cytotoxicity against the prostate cancer PC3 cell line were assayed by the MTT method. Compound 3 showed strong activity while the remaining compounds showed weak activity.

References

Jun 28, 2001·The Journal of Antibiotics·T TomikawaY Hayakawa
Oct 11, 2002·The Journal of Antibiotics·Yi ZhangBaomin Feng
Jun 29, 2005·The Journal of Antibiotics·Simone RochfortDavid Rhodes
Jun 24, 2006·Journal of Natural Products·Rui LiuHongbing Liu
Apr 23, 2010·Natural Product Reports·Kirstin ScherlachChristian Hertweck
Dec 12, 2012·Journal of Agricultural and Food Chemistry·Yang HuXudong Zhu
Jun 20, 2014·Natural Product Research·Jinzhong XuXianwen Yang
Oct 2, 2014·Marine Drugs·Ying LiuJinzhong Xu

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Citations

May 1, 2020·Marine Drugs·Hee Jae Shin

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Methods Mentioned

BETA
nuclear magnetic resonance
NMR

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