Two novel compounds from the root bark of Morus alba L

Natural Product Research
Ming LiDongmei Ren

Abstract

Chemical investigation of the root bark of Morus alba led to the isolation of a new flavone, dioxycudraflavone A (1) and a new 2-arylbenzofuran, 5-hydroxyethyl moracin M (2), together with seven known compounds namely sanggenon V (3), morusin (4), morusignin L (5), licoflavone C (6), moracin C (7), alfafuran (8) and mulberrofuran G (9). The structure elucidation of these compounds was based on analyses of spectroscopic data including 1D, 2D NMR and HR-ESI-MS. All compounds were evaluated for the α-glucosidase inhibitory and cytotoxic activities. Compounds 2-4, 8 and 9 exhibited strong α-glucosidase inhibitory activities with IC50 less than 10 μM, while only 4 and 9 showed moderate cytotoxic effects against lung cancer cells.

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Citations

Mar 9, 2018·Natural Product Research·Xuewei WuDongmei Ren
Jan 31, 2020·Natural Product Research·Miaomiao WangDongmei Ren
Aug 26, 2020·Natural Product Research·Bruna de Almeida MartinsJacqueline Aparecida Takahashi
Aug 24, 2021·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Amina M DirirLina F Yousef

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Methods Mentioned

BETA
NMR
column chromatography

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