Two novel cucurbitacins, neocucurbitacins A and B, from the Brazilian folk medicine "Buchinha" (Luffa operculata) and their effect on PEBP2alphaA and OCIF gene expression in a human osteoblast-like Saos-2 cell line

Chemical & Pharmaceutical Bulletin
Nobuo KawaharaM Satake

Abstract

Two novel cucurbitacins designated as neocucurbitacins A (1), possessing inhibitory activity of polyoma enhancer binding protein 2alphaA (PEBP2alphaA) and osteoclastogenesis-inhibitory factor (OCIF) gene expression in human osteoblast-like cells, and B (2) were isolated from the fruit of Luffa operculata. Their structures have been determined by extensive spectroscopic investigation.

References

May 8, 1997·Biochemical and Biophysical Research Communications·E TsudaK Higashio
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·H YasudaT Suda
Jul 2, 1998·Biochemical and Biophysical Research Communications·A MizunoH Ozawa
May 1, 1967·Journal of Medicinal Chemistry·S M KupchanM D Grove

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