Two novel prediction models improve predictions of skin corrosive sub-categories by test methods of OECD Test Guideline No. 431

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Bertrand DesprezHorst W Fuchs

Abstract

Alternative test methods often use prediction models (PMs) for converting endpoint measurements into predictions. Two PMs are used for the skin corrosion tests (SCTs) of the OECD Test Guideline No. 431 (TG 431). One is specific to EpiSkin™ test method, whereas EpiDerm™, SkinEthic™ RHE and epiCS® share a common PM. These methods are based on reconstructed human epidermis models wherein cell viability values are measured. Their PMs allow translating those values into sub-categories of corrosive chemicals, Category 1A (Cat1A) and a combination of Categories 1B/1C (Cat1BC), and identifying non-corrosive (NC) chemicals. EpiSkin™'s PM already results in sufficiently accurate predictions. The common PM of the three others accurately identifies all corrosive chemicals but, for sub-categorization, an important fraction of Cat1BC chemicals (40-50%) is over-predicted as Cat1A. This paper presents a post-hoc analysis of validation data on a set of n=80 chemicals. It investigates: why this common PM causes these over-predictions and how two novel PMs that we developed (PMvar1 and PMvar2) improve the predictive capacity of these methods. PMvar1 is based on a two-step approach; PMvar2 is based on a single composite indicator of cell viability...Continue Reading

References

Aug 3, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J HoffmannH W Fuchs
Feb 4, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Helena KandárováMartin Rosdy
May 18, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Carine TornierAnne de Brugerolle de Fraissinette
Aug 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M D BarrattA P Worth
Aug 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J H FentemM Liebsch
Jan 7, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Nathalie AlépéeJosé Cotovio

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Citations

Jan 8, 2016·Drug and Chemical Toxicology·Taygun TimocinMehmet Topaktas
Feb 24, 2018·Critical Reviews in Toxicology·Nicole C KleinstreuerDirk Petersohn
Nov 14, 2017·Tissue Engineering. Part a·Arnout MieremetAbdoelwaheb El Ghalbzouri
Apr 17, 2018·Chemical Society Reviews·E Johan FosterJeff Youngblood
Oct 17, 2017·Annual Review of Pharmacology and Toxicology·Lorna EwartPeter Newham
Mar 7, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Parinaz AbdollahiyanAhad Mokhtarzadeh

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