Two pathways for importing GDP-fucose into the endoplasmic reticulum lumen function redundantly in the O-fucosylation of Notch in Drosophila.

The Journal of Biological Chemistry
Hiroyuki O IshikawaKenji Matsuno

Abstract

Notch is a transmembrane receptor that shares homology with proteins containing epidermal growth factor-like repeats and mediates the cell-cell interactions necessary for many cell fate decisions. In Drosophila, O-fucosyltransferase 1 catalyzes the O-fucosylation of these epidermal growth factor-like repeats. This O-fucose elongates, resulting in an O-linked tetrasaccharide that regulates the signaling activities of Notch. Fucosyltransferases utilize GDP-fucose, which is synthesized in the cytosol, but fucosylation occurs in the lumen of the endoplasmic reticulum (ER) and Golgi. Therefore, GDP-fucose uptake into the ER and Golgi is essential for fucosylation. However, although GDP-fucose biosynthesis is well understood, the mechanisms and intracellular routes of GDP-fucose transportation remain unclear. Our previous study on the Drosophila Golgi GDP-fucose transporter (Gfr), which specifically localizes to the Golgi, suggested that another GDP-fucose transporter(s) exists in Drosophila. Here, we identified Efr (ER GDP-fucose transporter), a GDP-fucose transporter that localizes specifically to the ER. Efr is a multifunctional nucleotide sugar transporter involved in the biosynthesis of heparan sulfate-glycosaminoglycan chains a...Continue Reading

References

Dec 17, 1992·The New England Journal of Medicine·A EtzioniR Gershoni-Baruch
Nov 1, 1992·The Journal of Cell Biology·G DavidH Van den Berghe
May 1, 1994·Mechanisms of Development·J F de Celis, A García-Bellido
Apr 30, 1999·Science·S Artavanis-TsakonasR J Lake
Aug 10, 2000·Nature·D J MoloneyT F Vogt
Aug 30, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·X Lin, N Perrimon
Oct 24, 2000·Current Opinion in Structural Biology·P M Berninsone, C B Hirschberg
Apr 9, 2001·Seminars in Cell & Developmental Biology·S B Selleck
Jul 4, 2001·The Journal of Clinical Investigation·C B Hirschberg
Sep 1, 2001·Biochimie·R Gerardy-SchahnH Bakker
Nov 8, 2001·The Journal of Biological Chemistry·Christophe RoosRisto Renkonen
Nov 6, 2002·Biochimica Et Biophysica Acta·Robert S Haltiwanger, Pamela Stanley
Jan 16, 2003·Cell·Tetsuya Okajima, Kenneth D Irvine
Mar 26, 2003·Glycobiology·Daniel J Becker, John B Lowe
May 22, 2003·Pflügers Archiv : European journal of physiology·Nobuhiro Ishida, Masao Kawakita
Jan 18, 2005·The Journal of Biological Chemistry·Yi Luo, Robert S Haltiwanger
Dec 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hiroyuki O IshikawaKenji Matsuno
Feb 6, 2007·The Journal of Biological Chemistry·Christina C HellbuschChristian Körner
Sep 1, 2007·The Journal of Endocrinology·Ulla-Maj Fiúza, Alfonso Martinez Arias

❮ Previous
Next ❯

Citations

Sep 1, 2012·Glycoconjugate Journal·Toshihiko Katoh, Michael Tiemeyer
Sep 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Tomonori AyukawaKenji Matsuno
Sep 15, 2010·The Journal of Biological Chemistry·Linchao LuPamela Stanley
Jun 30, 2012·The Journal of Biological Chemistry·Christoph GeislerDonald L Jarvis
Apr 7, 2010·Glycobiology·Hamed Jafar-NejadRodrigo Fernandez-Valdivia
Mar 31, 2012·Seminars in Immunopathology·Kerstin Lühn, Martin K Wild
Feb 28, 2013·The Journal of Biological Chemistry·Li LiuCarlos B Hirschberg
Dec 30, 2014·Current Biology : CB·Deepika VasudevanRobert S Haltiwanger
Sep 23, 2014·Developmental Biology·Lei FengFlorence L Marlow
May 6, 2015·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Miki Yamamoto-HinoSatoshi Goto
Mar 21, 2015·Biochimica Et Biophysica Acta·Mitsutaka OgawaTetsuya Okajima
Apr 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Miki Yamamoto-HinoSatoshi Goto
Feb 9, 2012·Biochemical and Biophysical Research Communications·Yuta SakaidaniTetsuya Okajima
Jun 5, 2016·Journal of Molecular Biology·Ariel OrellanaAdrian Moreno
Apr 22, 2017·Glycobiology·Michael SchneiderRobert S Haltiwanger
Apr 30, 2013·Nature Neuroscience·Sayaka U SekineTakahiro Chihara
Jan 22, 2020·Journal of Cellular and Molecular Medicine·Minzi DengHeli Liu
Apr 30, 2016·The Journal of Biological Chemistry·Kenjiroo MatsumotoKenji Matsuno
Aug 23, 2020·International Journal of Molecular Sciences·Chenyu MaYasuhiko Kizuka
Aug 30, 2019·Computational and Structural Biotechnology Journal·Barbara HadleyJoe Tiralongo
Oct 5, 2019·Molecular and Biochemical Parasitology·Santoshi Nayak, Sudip K Ghosh
Jul 13, 2021·Journal of Bioenergetics and Biomembranes·Qi LiLei Zhou
Aug 10, 2019·Biochemistry·Paulina SosickaHudson H Freeze

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

© 2022 Meta ULC. All rights reserved