Two patients with all-trans retinoic acid-resistant acute promyelocytic leukemia treated successfully with gemtuzumab ozogamicin as a single agent

International Journal of Hematology
A TakeshitaRyuzo Ohno

Abstract

Acute promyelocytic leukemia (APL) cells express a considerable level of CD33, which is the target of gemtuzumab ozogamicin (GO), and a significantly lower level of P-glycoprotein (P-gp). Therefore, GO is predicted to be a successful treatment for APL. In this article, we report on the GO treatment of 2 patients with APL, who had fully relapsed after induction therapy with all-trans retinoic acid (ATRA) following chemotherapy. Both patients had relapsed 3 times and were resistant to reinduction therapy with ATRA. GO (9 mg/m2) was administered on days 1 and 15. After GO treatment, both patients achieved complete hematologic and molecular remission. GO may be another promising agent for the treatment of ATRA-resistant relapsed APL when given as salvage chemotherapy.

References

Nov 15, 2002·International Journal of Hematology·Dan Douer

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Citations

May 1, 2007·Current Hematologic Malignancy Reports·István Molnár, Bayard L Powell
May 28, 2013·International Journal of Hematology·Akihiro Takeshita
Aug 24, 2006·International Journal of Hematology·Ritsuro SuzukiMasahiro Kami
Dec 15, 2010·Expert Opinion on Biological Therapy·Massimo Breccia, Francesco Lo-Coco
Aug 13, 2020·International Journal of Molecular Sciences·Laurène FenwarthNicolas Duployez

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