Two patients with bepridil-induced interstitial pneumonia

Circulation Journal : Official Journal of the Japanese Circulation Society
Masataka WatanabeAkira Yamashina

Abstract

Two patients developed bepridil-induced interstitial pneumonia during treatment of arrhythmia. The first patient was a 69-year-old man who received bepridil to maintain sinus rhythm in atrial fibrillation and who developed dyspnea on the 20th day after administration. The second patient was a 72-year-old man who received bepridil for paroxysmal atrial fibrillation and who developed dyspnea on the 60th day after administration. They were diagnosed with interstitial pneumonia on the basis of physical and imaging findings. The first patient was discharged after steroid pulse therapy, and the second patient after improvement of physical and imaging findings when bepridil was discontinued. Although a limited number of cases of bepridil-induced interstitial pneumonia have been reported, the disorder should be kept in mind as an important adverse reaction when breathlessness or dyspnea develops during administration of the drug.

References

Feb 1, 1997·The European Respiratory Journal·P Camus
Feb 1, 1997·The European Respiratory Journal·P FoucherP Camus
Nov 18, 2003·Heart·S GakuA Teruhiko
Jan 7, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuji NakazatoHiroyuki Daida
Jan 21, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yasuhiro SetoguchiYoshinosuke Fukuchi

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Citations

Dec 3, 2009·Internal Medicine·Toshiro SuzukiKeishi Kubo
Oct 22, 2013·Respiratory Medicine·Kei YamasakiHiroshi Mukae
Sep 4, 2015·Journal of Arrhythmia·Manabu MatsumotoShumpo Uemura

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