Two patterns of solar lentigines: a histopathological analysis of 40 Japanese women

The Journal of Dermatology
Nozomi YoneiYuki Yamamoto

Abstract

Solar lentigines are common acquired pigmented lesions on sun-exposed skin. Their histopathological features have been reported as large numbers of melanocytes at the base of clubbed and budding rete ridges. In this study, biopsies were taken from facial solar lentigines in 40 Japanese women, and the sections were stained using hematoxylin-eosin, Fontana-Masson, and immunostained for melanocytes and Langerhans cells in order to verify the histological patterns of Japanese patients. We characterized the histopathological features of solar lentigines on the face and identified two patterns: one pattern (20/40 cases) demonstrated a flattened epidermis with basal melanosis, and the other pattern (20/40 cases) showed epidermal hyperplasia with elongated rete ridges composed of deeply pigmented basaloid cells. We termed the former pattern the "flattened epidermis" group, and the latter the "budding" group, respectively. The flattened epidermis group showed a significantly thinner epidermis, more severe solar elastosis and fewer Langerhans cells in the epidermis as compared with the budding group. We concluded that more severely sun-damaged solar lentigines might show the changes observed in the flattened epidermis group. Langerhans c...Continue Reading

References

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Citations

Dec 25, 2012·Journal of the American Academy of Dermatology·Hye Jin ChungJason B Lee
Apr 21, 2016·Lasers in Surgery and Medicine·Vasanop VachiramonKumutnart Chanprapaph
Apr 19, 2013·The Journal of Dermatology·Tessin WatanabeOsamu Yamamoto
Feb 16, 2018·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·G JosseE Questel
Jul 31, 2019·International Journal of Molecular Sciences·Genji Imokawa
Nov 18, 2020·International Journal of Molecular Sciences·Chikako Yoshikawa-MurakamiMitsunori Fukuda
May 29, 2021·Pigment Cell & Melanoma Research·Hee Young KangMauro Picardo

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