Two peaks in pH dependence of renin-angiotensinogen reaction

Bioscience, Biotechnology, and Biochemistry
U M NasirY Nakamura

Abstract

The pH dependence of the reaction of purified recombinant human renin with purified recombinant sheep angiotensinogen was not a typical bell-shape but had two peaks, pH 6.4 and 8.9. The pH dependence of the reaction of human renin with human, hog, and rat angiotensinogens partially purified from plasma had a peak with a shoulder containing two peaks close together. These findings indicate that the reaction of renin with angiotensinogen involves at least two amino acid residues other than the two aspartic acid residues known to be involved and occurs at acidic pH and basic pH by two different pairs of these amino acid residues.

References

Apr 25, 1988·Nucleic Acids Research·M TadaK Murakami
Jan 1, 1982·Annual Review of Biochemistry·M A Ondetti, D W Cushman
Mar 26, 1980·Biochimica Et Biophysica Acta·K MurakamiT Inagami
Jun 10, 1980·Biochemistry·K S Misono, T Inagami

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Citations

Jan 11, 2007·Bioscience, Biotechnology, and Biochemistry·Tsutomu NakagawaYukio Nakamura
May 9, 2007·Bioscience, Biotechnology, and Biochemistry·Hideyuki IwataYukio Nakamura
Mar 15, 2015·American Journal of Hypertension·Jessica ThomasonMohammad Nasir Uddin
Oct 3, 1998·Bioscience, Biotechnology, and Biochemistry·Y InuiY Nakamura
Oct 12, 2010·Nature·Aiwu ZhouRandy J Read
Dec 29, 2020·Journal of Chemical Information and Modeling·Shuhua MaJana Shen

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