Two percent of HIV-positive U.S. blood donors are infected with non-subtype B strains

AIDS Research and Human Retroviruses
Eric L DelwartMichael P Busch

Abstract

To estimate the prevalence of HIV strains other than the predominant HIV-1B subtype in the U.S. blood donor population we genetically and serologically characterized HIV in infected blood donations collected throughout he United States from 1997 to mid-2000. Using a combination of DNA heteroduplex mobility and DNA sequence analyses of the env and gag regions of HIV-1 we determined that 285 of 312 infections were caused by HIV-1B and six by non-subtype B HIV-1 (four HIV-1C, one HIV-1AE, one HIV-1A). Genetic distances of greater than 14% in the envelope V3-V5 region of the four HIV-1C strains indicated that they did not share a recent common origin. HIV-1 group M, N, and O, and HIV-2 specific peptide serological testing of the 20 PCR-negative samples determined that one infection was caused by HIV-2 and none by HIV-1 group N and O. The major risk factor for infection with a non-HIV-1B strain was sex with an HIV-infected person from Africa although three of seven non-HIV-1B-infected subjects did not fit that category. For four of seven non-HIV-1B-infected subjects the subtype detected was consistent with the African country of origin of the infected person or of their sexual partner. The frequency of genetically confirmed non-subt...Continue Reading

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Citations

Feb 2, 2012·The Journal of Infectious Diseases·Eric DelwartUNKNOWN NHLBI-REDS-II Study Group
Jul 27, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marine KarchavaMonica M Parker
Apr 30, 2005·AIDS Research and Therapy·Karen S SlobodJulia L Hurwitz
Aug 15, 2008·AIDS Research and Therapy·Philip A ChanRami Kantor
Aug 17, 2005·Emerging Infectious Diseases·Bertine S AkouambaHugo Soudeyns
Aug 12, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Sarah L Fishman, Andrea D Branch
Jun 24, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jacqueline M AchkarPhillipe N Nyambi
Apr 20, 2006·Journal of Medical Virology·Catherine A BrennanJohn Hackett

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