Two-phase greedy pursuit algorithm for automatic detection and characterization of transient calcium signaling

IEEE Journal of Biomedical and Health Informatics
Chen KanHui Yang

Abstract

Ca(2+) plays an important role in the regulation of cellular functions. Local calcium events, e.g., calcium sparks, not only bring insights into Ca(2+) signaling but also contribute to the understanding of various cellular processes. However, it is challenging to detect calcium sparks, due to their transient properties and high level of nonstationary noises in microscopic images. Most of existing algorithms tend to have limitations for the detection of calcium sparks, e.g., empirically defined hard thresholds or poor applicability to nonstationary conditions. This paper presents a novel two-phase greedy pursuit (TPGP) algorithm for automatic detection and characterization of calcium sparks. In Phase I, a coarse-grained search is conducted across the whole image to identify the predominant sparks. In Phase II, adaptive basis function model is developed for the fine-grained representation of detected sparks. It may be noted that the proposed TPGP algorithms overcome the drawback of hard thresholding in most of previous approaches. Furthermore, the morphology of detected sparks is effectively modeled with multiscale basis functions in Phase II, thereby facilitating the analysis of physiological features. We evaluated and validated...Continue Reading

References

Mar 23, 2007·American Journal of Physiology. Cell Physiology·Eckard PichtDonald M Bers
Oct 13, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·H YangR Komanduri
Dec 18, 2007·Cell·David E Clapham
Feb 12, 2008·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·S G ChangM Vetterli
Oct 17, 2008·Physiological Reviews·Heping Cheng, W J Lederer
Jun 3, 2011·American Journal of Physiology. Cell Physiology·Peter BankheadJ Graham McGeown
Jun 6, 2012·IEEE Transactions on Nanobioscience·Hongbao CaoYu-Ping Wang
Aug 1, 2012·IEEE Transactions on Pattern Analysis and Machine Intelligence·Chiwoo Park Yu Ding
Nov 16, 2013·IEEE Journal of Biomedical and Health Informatics· Gang Liu, Hui Yang

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Citations

Apr 9, 2019·PeerJ·Martin LaasmaaMarko Vendelin

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