PMID: 6145228Jan 1, 1984

Two-phase teratology study with the synthetic prostaglandin ONO-802 given intravaginally to rats

Teratogenesis, Carcinogenesis, and Mutagenesis
J A PetrereF A de la Iglesia


The synthetic prostaglandin ONO-802 was administered intravaginally to Sprague Dawley rats at doses of 1.0, 0.5, and 0.125 mg/kg on days 6 through 15 of gestation. A vehicle control group was treated with pessaries that did not contain the drug while another group remained untreated. Body weight, food, water consumption, and clinical signs were monitored during the experiment. In Phase One, 20 pregnant animals from each group were sacrificed at term, major organs were weighted, and litter and fetal data were collected. In Phase Two ten dams per group were allowed to deliver their litters, and the offspring were evaluated for survival, growth, developmental signs, and physiological function. Selected F1 offspring were retained to assess learning and emotional behavior or reproductive capacity. Administration of either 0.5 or 1.0 mg/kg of ONO-802 resulted in a slight reduction in food consumption and body weight gain. Water consumption was increased both during and after the dosing period for the mid and high dose dams. Significantly increased weights for the heart, lungs, liver, adrenals, and ovaries and decreased weights for the thymus gland were noted at term sacrifice of the 1.0 mg/kg dams, whereas the 0.5 mg/kg group had inc...Continue Reading


Sep 1, 1975·Journal of Reproduction and Fertility·E C Tso, D Lacy
Mar 1, 1969·Journal of Morphology·M V Barrow, W J Taylor
Feb 16, 1972·Nature: New Biology·P B Marley
Mar 1, 1973·Prostaglandins·T V Persaud
Apr 1, 1973·Fertility and Sterility·A R Fuchs, E Mok
Jan 1, 1984·Teratogenesis, Carcinogenesis, and Mutagenesis·J A PetrereF A de la Iglesia


Jan 1, 1984·Teratogenesis, Carcinogenesis, and Mutagenesis·J A PetrereF A de la Iglesia

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