Two-Photon Fluorescent Molybdenum Disulfide Dots for Targeted Prostate Cancer Imaging in the Biological II Window

ACS Omega
Carrie SweetParesh Chandra Ray

Abstract

Molybdenum disulfide (MoS2) quantum dots (QDs) derived from this two-dimensional (2D) transition metal dichalcogenide are emerging zero-dimensional materials that possess very good optical properties. Bioimaging using light in the biological II window (950-1350 nm) is a next-generation approach that will allow clinicians to achieve deeper tissue imaging with better image contrast and reduced phototoxicity and photobleaching. This article reports the development of a water-soluble, zero-dimensional antibody-conjugated transition metal dichalcogenide MoS2 QD-based two-photon luminescence (TPL) probe for the targeted bioimaging of cancer cells in the biological II window. The data indicates that MoS2 QDs exhibit an extremely high two-photon absorption cross-section (σ = 58960 GM) and two-photon brightness (4.7 × 103 GM) because of the quantum confinement and edge effects. Experimental data show that anti-PSMA antibody-attached MoS2 QDs can be used for selective two-photon imaging of live prostate cancer cells using 1064 nm light because of the high two-photon brightness, very good photostability, and very good biocompatibility of these MoS2 QDs. The data demonstrate that the bioconjugated MoS2 QDs can distinguish targeted and nont...Continue Reading

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Citations

Jan 29, 2019·Current Topics in Medicinal Chemistry·Junfu ZhangJun Pang
Dec 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xuanyu CaoYuezhong Xian
Nov 19, 2020·Chemical Society Reviews·Nasuha RohaizadMartin Pumera
May 18, 2021·Bioactive Materials·Jianling WangKelong Ai

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Methods Mentioned

BETA
fluorescence microscopy
electron
X-ray
dynamic light scattering
enzyme-linked

Software Mentioned

A scent

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