Two physically, functionally, and developmentally distinct peritoneal macrophage subsets.

Proceedings of the National Academy of Sciences of the United States of America
Eliver Eid Bou GhosnLeonore A Herzenberg

Abstract

The peritoneal cavity (PerC) is a unique compartment within which a variety of immune cells reside, and from which macrophages (MØ) are commonly drawn for functional studies. Here we define two MØ subsets that coexist in PerC in adult mice. One, provisionally called the large peritoneal MØ (LPM), contains approximately 90% of the PerC MØ in unstimulated animals but disappears rapidly from PerC following lipopolysaccharide (LPS) or thioglycolate stimulation. These cells express high levels of the canonical MØ surface markers, CD11b and F4/80. The second subset, referred to as small peritoneal MØ (SPM), expresses substantially lower levels of CD11b and F4/80 but expresses high levels of MHC-II, which is not expressed on LPM. SPM, which predominates in PerC after LPS or thioglycolate stimulation, does not derive from LPM. Instead, it derives from blood monocytes that rapidly enter the PerC after stimulation and differentiate to mature SPM within 2 to 4 d. Both subsets show clear phagocytic activity and both produce nitric oxide (NO) in response to LPS stimulation in vivo. However, their responses to LPS show key differences: in vitro, LPS stimulates LPM, but not SPM, to produce NO; in vivo, LPS stimulates both subsets to produce N...Continue Reading

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Citations

Oct 26, 2011·Nature Reviews. Immunology·Andrew ChowMiriam Merad
May 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·William AlazawiGraham R Foster
Aug 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Silvia L LageKarina R Bortoluci
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