Two phytotoxic azaphilone derivatives from Chaetomium globosum , a fungal endophyte isolated from Amaranthus viridis leaves

Mycology
K G Nelum P PiyasenaYoshinori Fujimoto

Abstract

A fungal endophyte isolated from the leaves of the allelopathic plant Amaranthus viridis of the family Amaranthaceae was identified as Chaetomium globosum through molecular means using internal transcribed spacer (ITS) region of rDNA gene. This is the first report of the isolation of C. globosum from Amaranthaceae. Chromatographic separation of the EtOAc extract of the fungal fermentation in potato dextrose broth yielded two known chlorine-containing azaphilone derivatives, chaetomugilin D (1) and chaetomugilin J (2). Compounds 1 and 2 were found to show phytotoxic activity in the lettuce (Lactuca sativa) seed germination bioassay. The IC50 values of 1 and 2 for root growth inhibition were 24.2 and 22.6 ppm, respectively, while IC50 values for shoot growth inhibition were 27.8 and 21.9 ppm, respectively. Phytotoxic activities of the chaetomugilin group of compounds have been reported for the first time, although their antifungal, antimicrobial and cytotoxic activities are known.

References

Dec 19, 2002·Critical Reviews in Biotechnology·Gary A Strobel
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Feb 28, 2004·Journal of Natural Products·Gary StrobelJames Harper
May 29, 2004·Trends in Plant Science·Kari SaikkonenStanley H Faeth
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Citations

Nov 16, 2019·Natural Products and Bioprospecting·G R Nalin RathnayakeYoshinori Fujimoto
Jun 23, 2020·Natural Product Research·Mona M G SaadYoshihito Shiono
May 1, 2021·Toxins·Dan XuLigang Zhou

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Methods Mentioned

BETA
column chromatography
NMR

Software Mentioned

BLAST

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An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.