Two-pore channels: Regulation by NAADP and customized roles in triggering calcium signals.

Cell Calcium
Sandip PatelEugen Brailoiu

Abstract

NAADP is a potent regulator of cytosolic calcium levels. Much evidence suggests that NAADP activates a novel channel located on an acidic (lysosomal-like) calcium store, the mobilisation of which results in further calcium release from the endoplasmic reticulum. Here, we discuss the recent identification of a family of poorly characterized ion channels (the two-pore channels) as endo-lysosomal NAADP receptors. The generation of calcium signals by these channels is likened to those evoked by depolarisation during excitation-contraction coupling in muscle. We discuss the idea that two-pore channels can mediate a trigger release of calcium which is then amplified by calcium-induced calcium release from the endoplasmic reticulum. This is similar to the activation of voltage-sensitive calcium channels and subsequent mobilisation of sarcoplasmic reticulum calcium stores in cardiac tissue. We suggest that two-pore channels may physically interact with ryanodine receptors to account for more direct release of calcium from the endoplasmic reticulum in analogy with the conformational coupling of voltage-sensitive calcium channels and ryanodine receptors in skeletal muscle. Interaction of two-pore channels with other calcium release chann...Continue Reading

References

May 1, 1993·Developmental Biology·S S Shen, W R Buck
Apr 12, 1996·The Journal of Biological Chemistry·R AarhusH C Lee
Aug 1, 1997·British Journal of Pharmacology·A A GenazzaniA Galione
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·B VannierL Birnbaumer
Jun 23, 1999·Cell Calcium·S PatelA P Thomas
Feb 7, 2001·Biochemical and Biophysical Research Communications·K IshibashiM Imai
Sep 6, 2000·Nature Genetics·R BargalG Bach
Sep 28, 2000·Biochemical and Biophysical Research Communications·R A Billington, A A Genazzani
Apr 11, 2001·Pflügers Archiv : European journal of physiology·A MojzisováK Ondrias
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·M J BerridgeM D Bootman
Sep 29, 2001·Plant & Cell Physiology·T FuruichiS Muto
Oct 20, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D LimL Santella
Feb 28, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Feliciano Protasi
Jul 10, 2002·The Biochemical Journal·Martin HoheneggerAndreas Zidar
Jul 16, 2002·The Biochemical Journal·Richard Graeff, Hon Cheung Lee
Sep 12, 2002·The Journal of Biological Chemistry·Georgina BerridgeSandip Patel
Sep 25, 2002·Physiological Reviews·Michael Fill, Julio A Copello
Jan 28, 2003·Current Biology : CB·Grant C ChurchillAntony Galione
May 31, 2003·Nature Genetics·Rosario Rizzuto, Tullio Pozzan
Jun 12, 2003·Pflügers Archiv : European journal of physiology·Jose M CancelaOle H Petersen
Aug 19, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Francesco MocciaLuigia Santella
Oct 22, 2003·The Journal of Cell Biology·Julia V GerasimenkoOleg V Gerasimenko
Dec 9, 2003·The Journal of Biological Chemistry·Michiko YamasakiAntony Galione
Feb 27, 2004·The Biochemical Journal·Dev ChuramaniSandip Patel
Apr 20, 2004·Biology of the Cell·Sandip Patel
Jul 22, 2004·British Journal of Pharmacology·Richard A BillingtonArmando A Genazzani

❮ Previous
Next ❯

Citations

Sep 30, 2010·The Journal of Biological Chemistry·G Cristina BrailoiuEugen Brailoiu
Sep 10, 2011·The Journal of Biological Chemistry·Katja RietdorfAntony Galione
Oct 1, 2010·The Journal of Biological Chemistry·Eugen BrailoiuSandip Patel
Dec 22, 2010·The Journal of Biological Chemistry·Robert HooperSandip Patel
Jul 2, 2011·The Journal of Biological Chemistry·G Cristina BrailoiuEugen Brailoiu
Oct 23, 2012·The Journal of Biological Chemistry·Elena DeliuEugen Brailoiu
Jun 18, 2011·Molecular Biology and Evolution·Xinjiang Cai, David E Clapham
Sep 24, 2010·Cold Spring Harbor Perspectives in Biology·Maarten GeesBernd Nilius
Oct 29, 2010·Cold Spring Harbor Perspectives in Biology·Colin W Taylor, Stephen C Tovey
May 27, 2011·American Journal of Physiology. Cell Physiology·Elena DeliuEugen Brailoiu
Aug 21, 2012·World Journal of Biological Chemistry·Francesco MocciaFranco Tanzi
Jun 15, 2011·FEBS Letters·Miquel Barceló-TornsRoser Masgrau
Apr 4, 2015·Critical Reviews in Biochemistry and Molecular Biology·Andrey NikiforovMathias Ziegler
Dec 4, 2012·Cell Calcium·Sarah E Webb, Andrew L Miller
Nov 26, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thibaut Brunet, Detlev Arendt
May 3, 2013·The Biochemical Journal·Dev ChuramaniSandip Patel
Jan 21, 2012·Biochemical Society Transactions·Sandip Patel, Eugen Brailoiu
May 27, 2015·Biochemical Society Transactions·Jonathan S Marchant, Sandip Patel
Oct 14, 2011·The Biochemical Journal·Dev ChuramaniSandip Patel
Oct 14, 2011·The Biochemical Journal·Anthony J MorganAntony Galione
Oct 27, 2012·The Biochemical Journal·Hannah V McCueLee P Haynes
Jan 11, 2011·The Biochemical Journal·Francisco J AulestiaJavier García-Sancho
Sep 20, 2011·Seminars in Cell & Developmental Biology·Vera KoniecznyColin W Taylor
May 24, 2011·Biochimica Et Biophysica Acta·Natalia DionisioJuan A Rosado
Dec 4, 2014·Cell Calcium·Kartik VenkatachalamMichael X Zhu
Jul 6, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Helmut Plattner, Alexei Verkhratsky
Jan 18, 2018·Antioxidants & Redox Signaling·Tanveer SharifShashi Gujar
Sep 1, 2016·Journal of Cell Science·Bethan S KilpatrickSandip Patel
Oct 21, 2011·Physiological Reviews·Alberto DarszonClaudia L Treviño
Jul 31, 2019·Cold Spring Harbor Perspectives in Biology·Sarah E WebbAndrew L Miller
Jul 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bogdan DorofteiGabriela Simionescu
May 26, 2011·The Journal of Biological Chemistry·Gustavo J S PereiraSoraya S Smaili
Jul 20, 2012·Physiological Reviews·Luc Leybaert, Michael J Sanderson
Jan 11, 2019·Biochemical Society Transactions·Øyvind StrømlandMathias Ziegler
Dec 16, 2020·Membranes·Brunella TanciniLorena Urbanelli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.