Two prototype blood-pool agents for contrast-enhanced magnetic resonance angiography of the portal vein in pigs

Academic Radiology
D K ShibataJ A Nelson

Abstract

Macromolecular "blood-pool" agents such as polylysine-gadopentetate dimeglumine or albumin-gadopentetate dimeglumine, which provide prolonged intravascular enhancement, were tested as magnetic resonance (MR) angiography contrast agents for the portal vein in pigs. Phase-contrast MR angiography of the portal veins was performed on six pigs before and after intravenous administration of polylysine-gadopentetate dimeglumine (n = 3) or albumin-gadopentetate dimeglumine (n = 3). The contrast-to-noise ratio of the portal veins was improved by 74% and 52%, respectively, using polylysine-gadopentetate dimeglumine or albumin-gadopentetate dimeglumine. More branches of the intrahepatic portal veins were visualized on postcontrast images. Blood-pool paramagnetic contrast agents improved the visualization of hepatic vasculature using phase-contrast MR angiography in our experimental model.

References

Jan 1, 1992·Journal of Computer Assisted Tomography·G MarchalP Van Hecke
Aug 1, 1990·AJR. American Journal of Roentgenology·G MarchalA L Baert
Apr 1, 1990·Radiology·J L CreasyR M Kessler
May 1, 1990·Journal of Computer Assisted Tomography·A H MatsumotoE P Strecker
Mar 1, 1989·Journal of Computer Assisted Tomography·M E MoseleyR C Brasch
Jan 1, 1993·Journal of Magnetic Resonance Imaging : JMRI·V M RungeC Lee
Jul 1, 1993·AJR. American Journal of Roentgenology·R R Edelman

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