PMID: 8948627Nov 15, 1996Paper

Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors

Nucleic Acids Research
M DownesG E Muscat

Abstract

Rev-erbA alpha and RVR/Rev-erb beta/BD73 are orphan steroid receptors that have no known ligands in the 'classical sense'. These 'orphans' do not activate transcription, but function as dominant transcriptional silencers. The thyroid hormone receptor (TR) and the retinoic acid receptor (RAR) act as transcriptional silencers by binding corepressors (e.g. N-CoR/RIP13 and SMRT/TRAC-2) in the absence of ligands. The molecular basis of repression by orphan receptors, however, remains obscure, and it is unclear whether these corepressors mediate transcriptional silencing by Rev-erbA alpha and RVR. Recently, two new variants of N-CoR have been described, RIP13a and RIP13delta1. The characterisation of these splice variants has identified a second receptor interaction domain (ID-II), in addition to the previously characterised interaction domain (ID-I). This investigation utilised the mammalian two hybrid system and transfection analysis to demonstrate that Rev-erbA alpha and RVR will not efficiently interact with either ID-I or ID-II separately from RIP13a or RIP13delta1. However, they interact efficiently with a domain composed of ID-I and ID-II from RIP13a. Interestingly, the interaction of Rev-erbA alpha and RVR is strongest with I...Continue Reading

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Citations

Oct 22, 2003·Molecular Genetics and Metabolism·Robert Clipsham, Edward R B McCabe
Feb 12, 1998·The Journal of Steroid Biochemistry and Molecular Biology·P J BaileyG E Muscat
Nov 27, 2007·Nature Structural & Molecular Biology·Srilatha RaghuramFraydoon Rastinejad
Jan 23, 1999·The Journal of Biological Chemistry·S H Hong, M L Privalsky
Dec 3, 2010·The Journal of Biological Chemistry·Nirupama Gupta, Stephen W Ragsdale
Nov 9, 2011·The Journal of Biological Chemistry·Michael L GoodsonMartin L Privalsky
Jan 5, 2000·Genes & Development·L NagyJ W Schwabe
May 1, 2013·Genes & Development·Adrienne MottisJohan Auwerx
May 30, 2003·Molecular and Cellular Biology·Dmitri WiederschainZhi-Min Yuan
Feb 24, 2004·Annual Review of Physiology·Martin L Privalsky
Apr 30, 2011·Future Medicinal Chemistry·Laura A SoltThomas P Burris
Mar 12, 2004·FEBS Letters·Hideyuki MigitaKohichi Kawai
Jul 2, 2014·Biochimica Et Biophysica Acta·Marta Kostrouchova, Zdenek Kostrouch
Jul 30, 2014·Trends in Endocrinology and Metabolism : TEM·Logan J Everett, Mitchell A Lazar
Sep 18, 2007·Journal of Molecular Biology·Eui-Jeon WooSeong Eon Ryu
May 8, 2001·Annual Review of Biophysics and Biomolecular Structure·A C SteinmetzD Moras
Sep 16, 2015·Cold Spring Harbor Symposia on Quantitative Biology·Bin Fang, Mitchell A Lazar
Jun 27, 2000·Journal of Molecular Recognition : JMR·S B NaglT F Smith
Jan 1, 2015·Journal of Experimental Neuroscience·Ana Maria OlivaresNeena B Haider
Apr 11, 2006·Nuclear Receptor Signaling·Michael GoodsonMartin A Privalsky
Oct 26, 1999·Endocrine Reviews·V Giguère
Feb 21, 2009·Molecular Endocrinology·Juliette RambaudGérard Benoit
Nov 30, 2006·Pharmacological Reviews·Gérard BenoitVincent Laudet

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